| 陈小凤,张浩,林裕霖,杨佳达,熊小丽,吴佳琳,范伟雄,杨志企.基于沿血管周围间隙弥散张量成像分析指数评估年龄相关类淋巴系统功能变化[J].中国医学影像技术,2025,41(10):1659~1662 |
| 基于沿血管周围间隙弥散张量成像分析指数评估年龄相关类淋巴系统功能变化 |
| Diffusion tensor imaging analysis index along the perivascular space for assessing age-related functional changes in glymphatic system |
| 投稿时间：2025-01-21 修订日期：2025-07-11 |
| DOI：10.13929/j.issn.1003-3289.2025.10.011 |
| 中文关键词: 脑 内环境稳定 年龄因素 弥散张量成像 |
| 英文关键词:brain homeostasis age factors diffusion tensor imaging |
| 基金项目:梅州市人民医院科研培育项目(PY-C2024027)。 |
| 作者 | 单位 | E-mail | | 陈小凤 | 梅州市人民医院放射科, 广东 梅州 514031
广东省临床分子诊断与抗体药物工程技术研究中心, 广东 梅州 514031 | | | 张浩 | 梅州市人民医院放射科, 广东 梅州 514031 | | | 林裕霖 | 梅州市人民医院放射科, 广东 梅州 514031 | | | 杨佳达 | 梅州市人民医院放射科, 广东 梅州 514031 | | | 熊小丽 | 梅州市人民医院放射科, 广东 梅州 514031 | | | 吴佳琳 | 梅州市人民医院放射科, 广东 梅州 514031 | | | 范伟雄 | 梅州市人民医院放射科, 广东 梅州 514031 | | | 杨志企 | 梅州市人民医院放射科, 广东 梅州 514031
广东省临床分子诊断与抗体药物工程技术研究中心, 广东 梅州 514031 | y13643090854@163.com |
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| 中文摘要: |
| 目的 观察基于沿血管周围间隙弥散张量成像分析(DTI-ALPS)指数评估年龄相关类淋巴系统(GS)功能变化的价值。方法 回顾性收集梅州市人民医院27名健康人和神经影像信息学工具与资源协作数据库中100名健康人的颅脑MR T1加权磁化准备快速梯度回波(T1-MPRAGE)和DTI数据,根据年龄划分青年组(n=38)、中年组(n=57)与老年组(n=32);利用DTI-ALPS指数分析自动化程序校正人为误差并获取DTI-ALPS指数;比较组间一般资料、神经心理学评估结果及DTI-ALPS指数;以Spearman相关分析观察DTI-ALPS指数与年龄、性别及神经心理学评估指标间的相关性。结果 青年组、中年组及老年组平均年龄分别为(28.5±5.8)岁、(53.7±6.8)岁及(73.8±2.3)岁。中年组与老年组DTI-ALPS指数差异无统计学意义(P＞0.05)且均低于青年组(P均＜0.05)。DTI-ALPS指数与年龄呈低度负相关(rs=－0.340,P＜0.001),而与性别及神经心理学评估结果均无明显相关(P均＞0.05)。结论 DTI-ALPS指数与健康人群年龄呈负相关,具有用于评估年龄相关GS功能变化的潜力。 |
| 英文摘要: |
| Objective To explore the value of diffusion tensor imaging analysis index along the perivascular space (DTI-ALPS) for assessing age-related functional changes in glymphatic system (GS). Methods Totally 27 healthy subjects from Meizhou Peoples Hospital and 100 healthy subjects from neuroimaging informatics tools and resources collaborator database who underwent T1-weighted magnetization-prepared rapid gradient echo (T1-MPRAGE) and DTI scanning were retrospectively enrolled and divided into youth group (n=38), middle-aged group (n=57) and elderly group (n=32). Automated DTI-ALPS index analysis procedure was used to minimize manual errors and derive DTI-ALPS index. The general data, neuropsychological assessment results and DTI-ALPS indices were compared among groups. Spearman correlation analysis was performed to observe the relationships of DTI-ALPS index and age, gender, as well as neuropsychological scores. Results The average age in youth group, middle-aged group and elderly group was (28.5±5.8), (53.7±6.8) and (73.8±2.3) years, respectively. No significant difference of DTI-ALPS index was found between middle-aged group and elderly group (P＞0.05), which were both lower than that in youth group (both P＜0.05). DTI-ALPS index was weakly negatively correlated with age (rs=－0.340,P＜0.001), but not significantly correlated with gender nor neuropsychological assessment results (both P＞0.05). Conclusion DTI-ALPS index was negatively correlated with age in healthy individuals, hence having potential utility for assessing age-related functional changes in GS. |
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