| 王猛,陈莉,孙朋辉,韩彦江.新型PET显像探针纳米抗体研究进展[J].中国医学影像技术,2025,41(5):835~838 |
| 新型PET显像探针纳米抗体研究进展 |
| Research progresses of novel PET imaging probes nanobodies |
| 投稿时间：2024-07-16 修订日期：2025-03-10 |
| DOI：10.13929/j.issn.1003-3289.2025.05.030 |
| 中文关键词: 纳米粒子 分子探针 正电子发射断层显像 |
| 英文关键词:nanoparticles molecular probes positron-emission tomography |
| 基金项目:广州市重点研发计划(2024B03J0631)、广东省医学科学技术研究基金(B2024239)、东莞市社会发展科技项目(20231800935972)。 |
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| 中文摘要: |
| 纳米抗体(Nb)因分子质量小、稳定性及渗透性强、可通过血脑屏障、免疫原性低等优势而成为替代传统抗体的PET显像新型探针,应用前景广阔。本文围绕Nb结构特征、正电子同位素标记方法及标记产物在PET显像中的应用进展进行综述。 |
| 英文摘要: |
| Nanobodies (Nb) have become novel probes for PET imaging instead of traditional antibodies, which have broad application prospects due to advantages of small molecular weight, strong stability and permeability, passing through the blood-brain barrier and low immunogenicity. The research progresses of structural characteristics of Nb, labeling methods of positron isotopes and application of labeled products in PET imaging were reviewed in this article. |
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