| 黄丽娜,李晓露,卜书婷,范国光.神经退行性疾病认知功能与代谢通路的MRI与PET研究进展[J].中国医学影像技术,2025,41(5):821~825 |
| 神经退行性疾病认知功能与代谢通路的MRI与PET研究进展 |
| MRI and PET research progresses in cognitive function and metabolic pathways of neurodegenerative diseases |
| 投稿时间：2024-11-26 修订日期：2025-04-06 |
| DOI：10.13929/j.issn.1003-3289.2025.05.027 |
| 中文关键词: 神经变性疾病 认知障碍 脑化学 磁共振成像 正电子发射型体层摄影术 |
| 英文关键词:neurodegenerative diseases cognitive dysfunction brain chemistry magnetic resonance imaging positron-emission tomography |
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| 中文摘要: |
| 阿尔茨海默病(AD)及帕金森病(PD)是常见神经退行性疾病,均可表现为认知功能障碍;其认知相关代谢通路存在共性而亦有所差异,可能涉及不同发病机制。利用MRI可间接评估代谢通路的结构与功能变化;PET则能用于评估脑代谢活性及功能连接。联合应用MRI与PET可为解析神经结构与功能提供互补信息。本文就MRI与PET神经影像学研究神经退行性疾病所致认知障碍进展进行综述。 |
| 英文摘要: |
| Alzheimer disease (AD) and Parkinson disease (PD) are both common neurodegenerative disorders, which can manifest as cognitive impairments. AD and PD have overlapping and distinct features in cognition-related metabolic pathways, potentially reflecting different underlying mechanisms. MRI can indirectly assess structural and functional changes in metabolic pathways, while PET can evaluate cerebral metabolic activity and functional connectivity. Integration of MRI and PET may provide complementary insights into neural structure and function. This review summarized research progresses in the application of MRI and PET for neuroimaging studies of cognitive impairment in neurodegenerative diseases. |
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