| 樊敏,马雷,史讯.18F-FDG PET/CT代谢参数鉴别非小细胞肺癌术后良、恶性线缘结节状增厚[J].中国医学影像技术,2025,41(5):744~748 |
| 18F-FDG PET/CT代谢参数鉴别非小细胞肺癌术后良、恶性线缘结节状增厚 |
| 18F-FDG PET/CT metabolic parameters for differentiating benign and malignant nodular thickening around staple line after resection of non-small cell lung cancer |
| 投稿时间：2024-11-09 修订日期：2025-04-07 |
| DOI：10.13929/j.issn.1003-3289.2025.05.010 |
| 中文关键词: 癌,非小细胞肺 复发 氟脱氧葡萄糖F18 正电子发射型X线计算机断层扫描 |
| 英文关键词:carcinoma, non-small-cell lung recurrence fluorodeoxyglucose F18 positron emission tomography computed tomography |
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| 中文摘要: |
| 目的 观察18F-FDG PET/CT代谢参数鉴别非小细胞肺癌(NSCLC)术后良、恶性线缘结节状增厚的价值。方法 回顾性纳入50例接受18F-FDG PET/CT检查的NSCLC术后患者、共52处线缘结节状增厚病灶,其中31例31处为NSCLC复发(复发组)、19例21处为良性病变(非复发组)。比较组间18F-FDG PET/CT代谢参数,包括最大标准摄取值(SUVmax)、肿瘤代谢体积(MTV)、糖酵解总量(TLG)及病灶SUVmax/纵隔血池SUVmax(SUVmax-ratio);针对组间有统计学差异的代谢参数绘制受试者工作特征(ROC)曲线,以曲线下面积(AUC)评估其鉴别NSCLC术后线缘良、恶性结节状增厚的价值。结果 复发组病灶SUVmax、TLG及SUVmax-ratio均高于非复发组(P均＜0.05);组间病灶MTV差异无统计学意义(P＞0.05)。以SUVmax、TLG及SUVmax-ratio评估NSCLC术后良、恶性线缘结节状增厚病灶的AUC分别为0.854、0.805及0.887,差异均无统计学意义(P均＞0.05)。结论 18F-FDG PET/CT代谢参数可有效鉴别NSCLC术后良、恶性线缘结节状增厚。 |
| 英文摘要: |
| Objective To observe the value of 18F-FDG PET/CT metabolic parameters for differentiating benign and malignant nodular thickening around the staple line after resection of non-small cell lung cancer (NSCLC). Methods Fifty NSCLC patients after surgical resection who underwent 18F-FDG PET/CT examination were retrospectively collected, with a total of 52 lesions of nodular thickening around the staple line, including 31 lesions of recurrent NSCLC in 31 patients (recurrent group) and 21 benign lesions in 19 patients (non-recurrent group). 18F-FDG PET/CT metabolic parameters, including the maximum standard uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG) and the ratio of lesion's SUVmax to mediastinal blood pool SUVmax (SUVmax-ratio) were compared between groups. Receiver operating characteristic (ROC) curves were drew for parameters being statistically different between groups, and the area under the curve (AUC) was used to evaluate their diagnostic performance for distinguishing benign and malignant nodular thickening around the staple line after resection of NSCLC. Results SUVmax, TLG and SUVmax-ratio of lesions in recurrent group were all higher than those in non-recurrent group (all P＜0.05), while no significant difference of lesions' MTV was found between groups (P＞0.05). The AUC of SUVmax, TLG and SUVmax-ratio for differentiating malignant and benign nodular thickening around the staple line after resection of NSCLC was 0.854, 0.805 and 0.887, respectively, all were not statistically different (all P＞0.05). Conclusion 18F-FDG PET/CT metabolic parameters could be used to effectively differentiate malignant and benign nodular thickening around the staple line after resection of NSCLC. |
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