| 林天烨,张叶宁,杜雷,李清扬,孙少帅,孙楠,孙应实.乳腺癌伴情绪障碍患者全脑网络拓扑属性及功能连接改变[J].中国医学影像技术,2025,41(5):712~717 |
| 乳腺癌伴情绪障碍患者全脑网络拓扑属性及功能连接改变 |
| Changes of topological properties and functional connectivity of global brain network in breast cancer patients accompanied by emotional disorders |
| 投稿时间：2024-08-19 修订日期：2025-02-21 |
| DOI：10.13929/j.issn.1003-3289.2025.05.004 |
| 中文关键词: 乳腺肿瘤 磁共振成像 情绪障碍 前瞻性研究 |
| 英文关键词:breast neoplasms magnetic resonance imaging mood disorders prospective studies |
| 基金项目:北京市自然科学基金(7232017)、北京大学肿瘤医院科研基金(ZY202413)。 |
| 作者 | 单位 | E-mail | | 林天烨 | 北京大学肿瘤医院暨北京市肿瘤防治研究所医学影像科, 恶性肿瘤发病机制及转化研究教育部重点实验室, 北京 100142 | | | 张叶宁 | 北京大学肿瘤医院暨北京市肿瘤防治研究所康复科, 北京 100142 | | | 杜雷 | 北京大学肿瘤医院暨北京市肿瘤防治研究所医学影像科, 恶性肿瘤发病机制及转化研究教育部重点实验室, 北京 100142 | | | 李清扬 | 北京大学肿瘤医院暨北京市肿瘤防治研究所医学影像科, 恶性肿瘤发病机制及转化研究教育部重点实验室, 北京 100142 | | | 孙少帅 | 北京大学肿瘤医院暨北京市肿瘤防治研究所医学影像科, 恶性肿瘤发病机制及转化研究教育部重点实验室, 北京 100142 | | | 孙楠 | 北京大学肿瘤医院暨北京市肿瘤防治研究所医学影像科, 恶性肿瘤发病机制及转化研究教育部重点实验室, 北京 100142 | | | 孙应实 | 北京大学肿瘤医院暨北京市肿瘤防治研究所医学影像科, 恶性肿瘤发病机制及转化研究教育部重点实验室, 北京 100142 | sys27@163.com |
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| 中文摘要: |
| 目的 探索乳腺癌(BC)伴情绪障碍患者全脑网络拓扑属性和功能连接(FC)改变。方法 前瞻性收集43例女性BC患者(BC组)及43名年龄及受教育程度相匹配的健康对照(HC组)。对BC组以恐惧癌症复发量表总分(FCR-total)、恐惧癌症复发严重性因子(FCRI)、广泛性焦虑量表-7(GAD-7)、抑郁筛查量表患者健康问卷(PHQ-9)进行评分,对其中40例行焦虑敏感指数(ASI-3)、健康焦虑元认知量表(MCQ-HA)及欧洲五维度五水平健康量表(EQ-5D-5L)评分;对HC组行GAD-7及PHQ-9量表评分。基于静息态功能MRI(rs-fMRI)分析2组全脑网络拓扑属性和FC,对比组间全脑网络拓扑属性指标,观察BC组全脑FC强度(FCS)值与各临床量表评分相关的脑区,并行脑区FCS空间相似性分析;观察BC组脑区水平FCS值与临床量表评分的相关性。结果 BC组均伴情绪障碍,其聚类系数低于HC组(t=－2.261,P=0.027)。BC组感觉运动网络及高阶脑网络等脑区FCS值与各临床量表评分相关,且各临床量表评分相关脑区FCS值存在相关性;BC组右侧丘脑腹外侧核及尾状核FCS与FCR-total(r=0.459,P=0.004)及FCRI(r=0.488,P=0.005)均呈正相关。结论 BC伴情绪障碍患者存在脑功能分离失调、右侧丘脑腹外侧核及尾状核等脑区FCS增强。 |
| 英文摘要: |
| Objective To explore changes of topological properties and functional connectivity (FC) of global brain network in breast cancer (BC) patients accompanied by emotional disorders. Methods Forty-three female BC patients (BC group) and 43 age- and education-matched healthy controls (HC group) were prospectively enrolled. The scores of fear of cancer recurrence-total (FCR-total), fear of cancer recurrence inventory (FCRI), general anxiety disorder-7 (GAD-7) and patient health questionnaire-9 (PHQ-9) for 43 patients in BC group, as well as of anxiety sensitivity index-3 (ASI-3), meta-cognitions about health questionnaire (MCQ-HA) and EuroQoL 5-dimension 5-level questionnaire (EQ-5D-5L) for 40 patients in BC group were obtained to evaluate emotional disorders. Meanwhile, the scores of GAD-7 and PHQ-9 were obtained in HC group to exclude for anxiety and depression. Using resting-state functional MRI (rs-fMRI), topological attributes and FC of global brain network were analyzed, and the topological attribute indicators of global brain network were compared between groups. Based on voxel-wise analysis, the regions in global brain related to FC strength (FCS) correlated with each clinical scale score in BC group were analyzed, and spatial similarity analysis of FCS was performed. The correlations of FCS at brain region level and clinical scale scores in BC group were observed. Results All patients in BC group were accompanied by emotional disorders. The clustering coefficient in BC group was lower than that in HC group (t=－2.261, P=0.027). Brain regions related to FCS values correlated with each clinical scale score in BC group were widely distributed in sensorimotor network and higher-order brain network, etc., and their FCS values were correlated. FCS of ventrolateral nucleus of right thalamus and caudate nucleus were positively correlated with FCR-total (r=0.459, P=0.004) and FCRI (r=0.488, P=0.005). Conclusion BC patients with emotions disorders had dysfunction of brain functional segregation, as well as enhanced FCS in brain regions such as ventrolateral nucleus of right thalamus and caudate nucleus. |
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