| 郝申,张瑶瑶,曲宗金,刘继国,王德广.自制自凝牙托粉头盔用于PET/CT扫描成年大鼠[J].中国医学影像技术,2025,41(5):697~700 |
| 自制自凝牙托粉头盔用于PET/CT扫描成年大鼠 |
| Self-made self-coagulating denture power helmet for PET/CT scanning of adult rats |
| 投稿时间：2025-03-17 修订日期：2025-05-20 |
| DOI：10.13929/j.issn.1003-3289.2025.05.001 |
| 中文关键词: 大鼠 脑 正电子发射断层显像和计算机体层摄影术 自制自凝牙托粉头盔 |
| 英文关键词:rats brain positron-emission tomography and computed tomography self-made self-coagulating dental power helmet |
| 基金项目:山东省重点研发计划(2019JZZY021003)。 |
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| 中文摘要: |
| 目的 观察自制自凝牙托粉头盔(简称自制头盔)用于PET/CT扫描成年大鼠的价值。方法 选取11只体质量290~300 g的成年健康雄性SD大鼠,以其中1只作为参照,采用自凝牙托粉自制厚度2 mm的头盔固定其头部。将10只大鼠随机均分为A、B组,每组5只,利用自制头盔固定其头部,采集18F-FDG PET(扫描时间20 min)及CT图像;对B组大鼠于采集PET第11分钟向右后爪底注射5%甲醛溶液0.10 ml,建立疼痛模型。观察A组18F-FDG PET/CT图像质量,对比基于CT所测A组为头盔覆盖的嗅球与无头盔覆盖的枕骨后区软组织CT灰度值;分析B组致痛前、后PET图像质量,评估头盔固定效果,并基于PET图像观察致痛后大脑第一躯体感觉皮质后肢区(S1HL)18F-FDG标准摄取值比值(SUVR)变化。结果 A组PET及CT图像清晰,无明显异物伪影,嗅球与枕骨后区软组织CT灰度值分别为257.0±50.7及194.4±55.4,差异无统计学意义(P=0.054)。B组致痛前、后PET图像均无明显伪影,头盔覆盖区与非覆盖区之间延续性较好;致痛后对侧S1HL明显激活,其SUVR致痛后/SUVR致痛前比值为1.19±0.07,SUVR致痛后高于SUVR致痛前(P=0.001)。结论 利用自制自凝牙托粉头盔能在PET/CT扫描过程中有效固定成年大鼠头部。 |
| 英文摘要: |
| Objective To observe the value of self-made self-coagulating denture power helmet for PET/CT scanning of adult rats. Methods Eleven adult healthy male SD rats with body weight of 290—300 g were selected. Taken 1 rat's head as a reference, a self-made helmet with a thickness of 2 mm was obtained using self-coagulating denture powder to fix the rat's head. Then the other 10 rats were randomly divided into group A and group B (each n=5). The heads of rats were fixed with helmets, and 18F-FDG PET (scanning time 20 min) and CT images were acquired. Pain models were constructed using rats in group B through injection of 5% formaldehyde solution 0.10 ml at the right foot at the 11th minute during PET collection. The imaging quality of 18F-FDG PET/CT in group A was observed, and CT gray values of the olfactory bulb covered by helmet and soft tissue area posterior occipital region without helmet coverage in group A were compared. The quality of PET images before and after pain induction in group B were analyzed to evaluate the fixation effect of helmet. Based on PET images, the changes of 18F-FDG standard uptake value ratio (SUVR) in primary somatosensory cortex hindlimb region (S1HL) in group B after pain induction were observed. Results PET and CT images in group A were clear, with no obvious foreign body artifacts. CT gray values of olfactory bulb and soft tissue in posterior occipital region in group A was 257.0±50.7 and 194.4±55.4, respectively, being not significantly different (P=0.054). PET images before and after pain induction in group B showed no obvious artifacts, and the continuity between covered area of helmet and non-covered area was good. After pain induction, S1HL on the contralateral side of pain induction in group B significantly activated. The ratio of SUVRafter pain induction/SUVRbefore pain induction in S1HL on the contralateral side of pain induction was 1.19±0.07, and SUVRafter pain induction was higher than SUVRbefore pain induction (P=0.001). Conclusion Self-made self-coagulation denture powder helmet could effectively fix head of adult rat during PET/CT scanning. |
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