| 吴雅琳,丁必彪,张宏,余玉盛,许定虎,程晓光.基于定量CT分析腰椎骨密度与血尿酸、肝脏脂肪及腹部脂肪的相关性[J].中国医学影像技术,2025,41(4):637~641 |
| 基于定量CT分析腰椎骨密度与血尿酸、肝脏脂肪及腹部脂肪的相关性 |
| Correlations of lumbar bone mineral density with serum uric acid, hepatic fat and abdominal fat based on quantitative CT |
| 投稿时间：2024-09-20 修订日期：2025-01-10 |
| DOI：10.13929/j.issn.1003-3289.2025.04.027 |
| 中文关键词: 骨密度 腹部脂肪 脂肪肝 高尿酸血症 体层摄影术,X线计算机 |
| 英文关键词:bone density abdominal fat fatty liver hyperuricemia tomography, X-ray computed |
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| 中文摘要: |
| 目的 基于定量CT(QCT)分析腰椎骨密度(BMD)与血尿酸(SUA)、肝脏脂肪及腹部脂肪的相关性。方法 回顾性收集接受腰椎QCT检查的522人;根据SUA水平将不同性别人群分为高尿酸血症(HUA)组及SUA正常组,比较组间QCT参数;同时根据腰椎BMD将不同性别人群分为骨量正常组(简称正常组)、骨量减少组(简称减少组)及骨质疏松症(OP)组,比较组间SUA及QCT参数;以Pearson相关分析观察不同性别腰椎BMD与年龄、SUA、内脏脂肪组织(VAT)、皮下脂肪组织(SAT)及肝脏脂肪含量的相关性。结果 男性325人,包括HUA组105例、SUA正常组220名;女性197人,包括HUA组26例、SUA正常组171名。不同性别HUA组VAT、SAT及肝脏脂肪含量百分比均高于SUA正常组(P均＜0.05)。男性中,正常组196名、减少组105例、OP组24例,其间VAT依次递增(P均＜0.05);女性中,正常组147名、减少组30例、OP组20例,其间VAT及SAT均依次递增(P均＜0.05)。男性腰椎BMD与年龄及VAT分别呈中度及弱负相关(r=－0.618、－0.286,P均＜0.001),女性腰椎BMD与年龄、VAT及SAT分别呈中度、低度及弱负相关(r=－0.772、－0.451、－0.273,P均＜0.001)。结论 SUA水平升高可致腹部及肝脏脂肪含量增加;后者与腰椎BMD呈负相关。 |
| 英文摘要: |
| Objective To observe the correlations of lumbar bone mineral density (BMD) with serum uric acid (SUA), hepatic fat and abdominal fat based on quantitative CT (QCT). Methods A total of 522 subjects who underwent lumbar QCT were retrospectively enrolled. Subjects with different genders were divided into hyperuricemia (HUA) group and normal SUA group according to SUA levels, and QCT parameters were compared between groups. Meanwhile, subjects with different genders were also divided into normal bone mass group (normal group), osteopenia group and osteoporosis (OP) group, and SUA and QCT parameters were compared among groups. Pearson correlation analyses were performed to explore the correlations of lumbar BMD with age, SUA, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and liver fat content. Results There were 325 males, with 105 ones in HUA group and 220 ones in normal SUA group. There were 197 females, with 26 ones in HUA group and 171 ones in normal SUA group. VAT, SAT and percentage of liver fat content in HUA group of different genders were all higher than those in normal SUA group (all P＜0.05). Among 325 males, there were 196 ones in normal group, 105 ones in osteopenia group and 24 ones in OP group among males, and VAT increased successively in the above groups (all P＜0.05). Among 197 females, there were 147 ones in normal group, 30 ones in osteopenia group and 20 ones in OP group, and VAT and SAT increased successively in the above groups (all P＜0.05). Lumbar BMD was moderately and weakly negatively correlated with age and VAT in males (r=－0.618, －0.286, both P＜0.001), which was moderately, lowly and weakly negatively correlated with age, VAT and SAT in females, respectively (r=－0.772, －0.451, －0.273, all P＜0.001). Conclusion Increased SUA levels resulted in increased abdominal and liver fat content, and the latter was negatively correlated with lumbar BMD. |
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