| 罗莹莹,阳依宏,尤志雯,陈兴,周子荣,袁增贝,王海峰,赵军,王海岩.18F-PSMA-1007 PET/MRI诊断前列腺癌侵犯精囊腺[J].中国医学影像技术,2025,41(2):310~315 |
| 18F-PSMA-1007 PET/MRI诊断前列腺癌侵犯精囊腺 |
| 18F-PSMA-1007 PET/MRI for diagnosing seminal vesicle invasion of prostatic cancer |
| 投稿时间：2024-09-14 修订日期：2024-12-16 |
| DOI：10.13929/j.issn.1003-3289.2025.02.027 |
| 中文关键词: 前列腺肿瘤 精囊 正电子发射断层显像 磁共振成像 |
| 英文关键词:prostatic neoplasms seminal vesicles positron-emission tomography magnetic resonance imaging |
| 基金项目:浦东新区卫生系统学科建设重点学科(PWZxk2022-12)。 |
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| 中文摘要: |
| 目的 观察18F-前列腺特异性膜抗原(PSMA)-1007 PET/MRI诊断前列腺癌(PCa)侵犯精囊腺(SVI)的价值。方法 回顾性纳入92例接受根治性前列腺癌切除术的男性PCa患者,根据术后病理所见有无SVI将其分为阳性组(n=26)与阴性组(n=66)。比较组间PCa病灶PET/MRI参数,包括最大标准摄取值(SUVmax)、最小表观弥散系数(ADCmin)、平均表观弥散系数(ADCmean)、SUVmax/ADCmin、SUVmax/ADCmean、PSMA肿瘤体积(PSMA-TV)及PSMA表达总量(TL-PSMA);绘制受试者工作特征曲线,评估各参数诊断SVI的效能。结果 92例中,18F-PSMA-1007 PET/MRI显示30例SVI、 62例无SVI,其诊断SVI的准确率为73.91%、敏感度为61.54%、特异度为78.79%、阳性预测值为53.33%、阴性预测值为83.87%。组间ADCmin、PSMA-TV及TL-PSMA差异均有统计学意义(P均＜0.05)。以SUVmax、ADCmin、ADCmean、SUVmax/ADCmin、SUVmax/ADCmean、PSMA-TV及TL-PSMA诊断PCa SVI的曲线下面积(AUC)分别为0.554、0.341、0.396、0.603、0.581、0.755及0.705;其中,PSMA-TV的AUC高于除TL-PSMA外其他参数,其敏感度为84.60%、特异度为56.10%。结论 18F-PSMA-1007 PET/MRI有助于诊断PCa SVI。 |
| 英文摘要: |
| Objective To observe the value of 18F-prostate specific membrane antigen (PSMA)-1007 PET/MRI for diagnosing seminal vesicle invasion (SVI) of prostatic cancer (PCa). Methods Totally 92 male patients with PCa who underwent radical prostatectomy were retrospectively enrolled and divided into positive group (n=26) and negative group (n=66) based on postoperative pathology showed SVI or not. PET/MRI parameters, including maximum standard uptake value (SUVmax), minimum apparent diffusion coefficient (ADCmin), mean apparent diffusion coefficient (ADCmean), SUVmax/ADCmin, SUVmax/ADCmean, PSMA tumor volume (PSMA-TV) and total lesion PSMA (TL-PSMA) were compared between groups. The receiver operating characteristic curve was drawn, and the efficacy of each parameter for diagnosing SVI was analyzed. Results Among 92 cases of PCa, 18F-PSMA-1007 PET/MRI showed 30 cases with SVI and 62 cases without SVI, with accuracy of 73.91%, sensitivity of 61.54%, specificity of 78.79%, positive predictive value of 53.33% and negative predictive value of 83.87%. Significant differences of ADCmin, PSMA-TV and TL-PSMA were found between groups (all P＜0.05). The area under the curve (AUC) of SUVmax, ADCmin, ADCmean, SUVmax/ADCmin, SUVmax/ADCmean, PSMA-TV and TL-PSMA for diagnosing SVI of PCa was 0.554, 0.341, 0.396, 0.603, 0.581, 0.755 and 0.705, respectively. The AUC of PSMA-TV was higher than other parameters except for TL-PSMA, with sensitivity of 84.60% and specificity of 56.10%. Conclusion 18F-PSMA-1007 PET/MRI was helpful for diagnosing SVI of PCa. |
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