| 邓学佳,杨帆,张奎.孕11~14周超声软指标用于预测不良妊娠结局:Meta分析[J].中国医学影像技术,2025,41(2):304~309 |
| 孕11~14周超声软指标用于预测不良妊娠结局:Meta分析 |
| Ultrasound soft markers at 11—14 weeks of gestation for predicting adverse pregnancy outcomes: Meta-analysis |
| 投稿时间：2024-07-31 修订日期：2024-09-03 |
| DOI：10.13929/j.issn.1003-3289.2025.02.026 |
| 中文关键词: 胎儿 妊娠结局 超声检查,产前 荟萃分析 |
| 英文关键词:fetus pregnancy outcome ultrasonography,prenatal meta-analysis |
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| 中文摘要: |
| 目的 采用meta分析观察孕11~14周超声软指标用于预测不良妊娠结局的价值。方法 检索2000年1月1日—2024年4月1日中国知网、万方医学网、维普数据库、PubMed、Cochrane Library、Embase及Web of Science数据库收录的以孕11~14周阳性超声软指标[包括颈项透明层(NT)增厚、鼻骨发育不良、静脉导管反向或缺失、三尖瓣反流、单脐动脉]预测不良妊娠结局的相关文献;由2名研究者独立筛选文献、提取资料并评价偏倚风险,采用Stata 17.0软件进行meta分析。结果 共纳入37篇文献、9 673名孕妇。meta分析结果显示,胎儿阳性超声软指标项越多,则不良妊娠结局风险越高。单一阳性指标中,单脐动脉胎儿不良妊娠结局发生率最高、NT≥3.0 mm胎儿染色体异常发生率最高,而三尖瓣反流胎儿不良妊娠结局及染色体异常发生率均最低。结论 孕11~14周超声软指标阳性对预测不良妊娠结局、尤其染色体异常具有一定价值。 |
| 英文摘要: |
| Objective To observe the value of ultrasound soft markers at 11—14 weeks of gestation for predicting adverse pregnancy outcomes using meta-analysis. Methods Literature about ultrasound soft markers at 11—14 weeks of gestation, including nuchal translucency (NT) thickening, nasal bone dysplasia, reversed or absent venous duct, tricuspid regurgitation and single umbilical artery, for predicting adverse pregnancy outcomes were searched in CNKI, Wanfang Med Online, VIP databases, PubMed, Cochrane Library, Embase and Web of Science databases from January 1, 2000 to April 1, 2024 by 2 researchers independently. The data were extracted, and the risk of bias was assessed. Stata 17.0 software was used for meta-analysis. Results Totally 37 articles involving 9 673 gravidas were enrolled. Meta-analysis showed that the more positive ultrasound soft markers at 11—14 weeks of gestation, the higher risk of adverse pregnancy outcomes. Among single positive markers, single umbilical artery had the highest incidence of adverse pregnancy outcomes, and NT≥3.0 mm had the highest incidence of chromosome abnormalities in fetuses, while tricuspid regurgitation suggested the lowest possibility of adverse pregnancy outcomes and chromosome abnormalities in fetuses. Conclusion Positive ultrasound soft markers at 11—14 weeks of gestation had certain predictive value for adverse pregnancy outcomes, especially chromosomal abnormalities. |
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