| 赵震宇,张露露,姚晓晨,张川,俞飞,宋结平,薛雪,邵国强,王峰.68Ga-DOTA-NOC PET/CT诊断嗜铬细胞瘤与副神经节瘤[J].中国医学影像技术,2025,41(2):268~272 |
| 68Ga-DOTA-NOC PET/CT诊断嗜铬细胞瘤与副神经节瘤 |
| 68Ga-DOTA-NOC PET/CT for diagnosing pheochromocytoma and paraganglioma |
| 投稿时间：2024-10-23 修订日期：2024-10-28 |
| DOI：10.13929/j.issn.1003-3289.2025.02.018 |
| 中文关键词: 嗜铬细胞瘤 副神经节瘤 正电子发射断层显像 体层摄影术,X线计算机 受体,生长抑素 |
| 英文关键词:pheochromocytoma paraganglioma positron-emission tomography tomography,X-ray computed receptors,somatostatin |
| 基金项目:江苏省医学重点学科/实验室建设单位(JSDW202247)、江苏省研究型医院建设单位(YJXYYJSDW1)。 |
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| 中文摘要: |
| 目的 观察68Ga-DOTA-NOC PET/CT诊断嗜铬细胞瘤(PCC)/副神经节瘤(PGL)的价值。方法 回顾性分析38例接受68Ga-DOTA-NOC PET/CT检查的疑诊或确诊PCC/PGL患者,其中20例同期接受131I-间碘苄胍(MIBG)SPECT/CT检查;与131I-MIBG SPECT/CT对比,分析68Ga-DOTA-NOC PET/CT在患者及病灶层面诊断PCC/PGL的价值。结果 38例中,PCC 20例、PGL 14例,肾上腺皮质腺癌1例、良性肾上腺增生3例。68Ga-DOTA-NOC PET/CT针对全部38例诊断PCC/PGL的敏感度、特异度、阳性预测值、阴性预测值及准确率分别为87.88%(29/33)、60.00%(3/5)、93.55%(29/31)、42.86%(3/7)及84.21%(32/38)。68Ga-DOTA-NOC PET/CT共于34例PCC/PGL中检出188处病灶,检出率89.95%(188/209)。对于同期接受2种检查的20例,68Ga-DOTA-NOC PET/CT对骨、淋巴结、肝及肺PCC/PGL转移灶检出率及总体病灶检出率均高于131I-MIBG SPECT/CT(P均＜0.05);2种方法诊断PCC/PGL准确率差异无统计学意义(P＞0.05)。结论 68Ga-DOTA-NOC PET/CT诊断PCC/PGL准确率与131I-MIBG SPECT/CT相当而对转移灶检出率更高,有助于评估PCC/PGL分期和风险分层。 |
| 英文摘要: |
| Objective To observe the value of 68Ga-DOTA-NOC PET/CT for diagnosing pheochromocytoma (PCC) and paraganglioma (PGL). Methods Thirty-eight patients with suspected or confirmed PCC/PGL who underwent 68Ga-DOTA-NOC PET/CT were retrospectively enrolled, among them 20 cases underwent 131I-metaiodobenzylguanidine (MIBG) SPECT/CT during the same period. The value of 68Ga-DOTA-NOC PET/CT for diagnosing PCC/PGL at individual and lesion levels were analyzed and compared to the results of 131I-MIBG SPECT/CT. Results Among 38 cases, there were 20 cases of PCC, 14 cases of PGL, 1 case of adrenocortical carcinoma and 3 cases of benign adrenal hyperplasia. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 68Ga-DOTA-NOC PET/CT for diagnosing PCC/PGL in all 38 cases was 87.88% (29/33), 60.00% (3/5), 93.55% (29/31), 42.86% (3/7) and 84.21% (32/38), respectively. Totally 188 lesions were detected in 34 cases, with detection rate of 89.95% (188/209). For 20 patients who underwent both 2 kinds examinations, the detection rate of bone, lymph node, liver, lung metastases and the overall lesions of 68Ga-DOTA-NOC PET/CT were all higher than those of 131I-MIBG SPECT/CT (all P＜0.05). No significant difference of diagnostic accuracy of PCC/PGL was found between 68Ga-DOTA-NOC PET/CT and 131I-MIBG SPECT/CT (P＞0.05). Conclusion The value of 68Ga-DOTA-NOC PET/CT for diagnosing PCC/PGL was comparable to that of 131I-MIBG SPECT/CT, but the former showed higher detection rate of metastases, hence being helpful to staging and risk stratification of PCC/PGL. |
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