| 王嫚,赵婧含,高冰冰,屈明睿,苗延巍.合成MRI评估帕金森病患者脑部核团及白质结构改变[J].中国医学影像技术,2025,41(2):239~244 |
| 合成MRI评估帕金森病患者脑部核团及白质结构改变 |
| Synthetic MRI for evaluating structural changes of brain nuclei and white matter in patients with Parkinson disease |
| 投稿时间：2024-09-20 修订日期：2024-11-03 |
| DOI：10.13929/j.issn.1003-3289.2025.02.012 |
| 中文关键词: 帕金森病 脑 磁共振成像 前瞻性研究 |
| 英文关键词:Parkinson disease brain magnetic resonance imaging prospective studies |
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| 中文摘要: |
| 目的 观察合成MRI(syMRI)评估帕金森病(PD)患者脑部核团及白质结构改变的价值。方法 前瞻性对45例PD患者(PD组)及35名健康对照者(HC组)行头部策略性采集梯度回波序列扫描,经后处理获得syMRI,测量各核团及脑白质T1、质子密度(PrD)、R2*值及磁敏感值(MSV)并进行组间比较。分析组间差异有统计学意义的syMRI定量参数与神经功能评分的相关性,并以多因素logistic回归分析建立联合模型。绘制受试者工作特征(ROC)曲线,评估各单一syMRI定量参数及联合模型诊断PD的效能。结果 相比HC组,PD组双侧尾状核T1值及PrD值均降低,双侧黑质及右侧红核MSV升高(FDR校正P均＜0.05);PD组双侧胼胝体压部的T1值及PrD值、左侧内囊后肢(PLIC) PrD值,以及双侧PLIC和右侧胼胝体膝部R2*值均降低(FDR校正P＜0.05)。上述脑区syMRI定量参数与个体蒙特利尔认知评估及汉密尔顿焦虑量表评分结果相关(r=－0.390~0.416,P均＜0.01)。以单一syMRI定量参数诊断PD的曲线下面积为0.664~0.788,低于联合模型的0.905(Z=2.653~4.096,P均＜0.05)。结论 syMRI可用于量化评估PD患者脑部核团及白质结构改变。 |
| 英文摘要: |
| Objective To investigate the value of synthetic MRI (syMRI) for evaluating structural changes of brain nuclei and white matter in patients with Parkinson disease (PD). Methods Forty-five PD patients (PD group) and 35 healthy controls (HC group) were prospectively enrolled. Head scanning with strategically acquired gradient echo sequence was performed, then syMRI was obtained with post-processing. The values of T1, proton density (PrD), R2* and magnetic sensitivity values (MSV) of nuclei and white matter were measured based on syMRI and compared between groups. The correlations of syMRI quantitative parameters of nuclei and white matter being significantly different between groups with neurological function scores of subject were analyzed, and a combined model was established using multivariate logistic regression analysis. Receiver operating characteristic (ROC) curve was drawn, the efficacy of single syMRI quantitative parameter and combined model for diagnosing PD was evaluated. Results Compared with HC group, T1 and PrD values of bilateral caudate nuclei decreased, while MSV of bilateral substatia nigra and right red nucleus increased (all FDR correction P＜0.05), while T1 and PrD values of bilateral splenium of corpus callosum, PrD values of left posterior limbs of the internal capsule (PLIC), R2* values of bilateral PLIC and right genu of the corpus callosum decreased in PD group (all FDR correction P＜0.05). syMRI quantitative parameters of the above brain regions were correlated with scores of Montreal cognitive assessment and Hamilton anxiety scale (r=－0.390—0.416, all P＜0.01). The area under the curve of single syMRI quantitative parameter for diagnosing PD was 0.664—0.788, lower than that of combined model (0.905, Z=2.653—4.096, all P＜0.05). Conclusion SyMRI could be used to quantitatively evaluate structural changes of brain nuclei and white matter in PD patients. |
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