| 朱侣明,侯军文,钟志民,葛璟洁,吴越,陈圣文,罗建华,杨贇豪,王静,林华媚,左传涛,管一晖.阿尔茨海默病患者大脑皮层厚度与β淀粉样蛋白病理性沉积的相关性[J].中国医学影像技术,2025,41(2):207~211 |
| 阿尔茨海默病患者大脑皮层厚度与β淀粉样蛋白病理性沉积的相关性 |
| Correlation between cortical thickness and pathological deposition of β-amyloid in patients with Alzheimer disease |
| 投稿时间：2024-09-03 修订日期：2024-12-05 |
| DOI：10.13929/j.issn.1003-3289.2025.02.006 |
| 中文关键词: 阿尔茨海默病 认知障碍 大脑皮质 淀粉样物质 磁共振成像 正电子发射断层显像 |
| 英文关键词:Alzheimer disease cognition disorders cerebral cortex amyloid magnetic resonance imaging positron-emission tomography |
| 基金项目: |
| 作者 | 单位 | E-mail | | 朱侣明 | 兴国县人民医院 赣南医科大学附属兴国医院医学影像科, 江西 赣州 342400 | | | 侯军文 | 兴国县人民医院 赣南医科大学附属兴国医院医学影像科, 江西 赣州 342400 | | | 钟志民 | 兴国县人民医院 赣南医科大学附属兴国医院医学影像科, 江西 赣州 342400 | | | 葛璟洁 | 复旦大学附属华山医院核医学/PET中心, 上海 200040 | lovejingjie@fudan.edu.cn | | 吴越 | 复旦大学附属华山医院放射科, 上海 200040 | | | 陈圣文 | 兴国县人民医院 赣南医科大学附属兴国医院医学影像科, 江西 赣州 342400 | | | 罗建华 | 兴国县人民医院 赣南医科大学附属兴国医院医学影像科, 江西 赣州 342400 | | | 杨贇豪 | 复旦大学附属华山医院核医学/PET中心, 上海 200040 | | | 王静 | 复旦大学附属华山医院核医学/PET中心, 上海 200040 | | | 林华媚 | 复旦大学附属华山医院核医学/PET中心, 上海 200040 | | | 左传涛 | 复旦大学附属华山医院核医学/PET中心, 上海 200040 | | | 管一晖 | 复旦大学附属华山医院核医学/PET中心, 上海 200040 | |
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| 中文摘要: |
| 目的 观察阿尔茨海默病(AD)源性轻度认知障碍(MCI)及痴呆患者大脑皮层厚度与β淀粉样蛋白(Aβ)病理性沉积的相关性。方法 前瞻性纳入22例AD,根据认知障碍程度将其分为痴呆组(n=12)及MCI组(n=10);同时招募17名无认知功能障碍的健康人作为对照组。行MR检查和18F-贝他苯(18F-FBB) PET显像,计算大脑皮层厚度和Aβ沉积值[即Centiloid(CL)值]并进行3组间及两两组间比较,分析其相关性。结果 痴呆组、MCI组及对照组大脑皮层厚度分别为(2.18±0.14)、(2.35±0.08)及(2.36±0.09) mm,3组间差异有统计学意义(P＜0.05);其中,痴呆组大脑皮层厚度显著低于MCI组及对照组(P均＜0.05)。痴呆组、MCI组及对照组CL值分别为77.97(63.07,95.55)、65.51(54.54,90.50)及－1.17(－9.66,4.88),3组间差异有统计学意义(P＜0.05);其中,痴呆组及MCI组均显著大于对照组(P均＜0.05)。MCI组大脑皮层厚度与CL值呈中度负相关(r=－0.580,P=0.048),而在其余2组二者无显著相关(P均＞0.05)。结论 AD源性MCI患者大脑皮层厚度与Aβ异常沉积呈中度负相关,而在痴呆期二者无明显相关。 |
| 英文摘要: |
| Objective To observe the correlation between cortical thickness and pathological deposition of β-amyloid (Aβ) in patients with Alzheimer disease (AD) induced mild cognitive impairment (MCI) or dementia. Methods Totally 22 AD patients were prospectively enrolled and divided into dementia group (n=12) and MCI group (n=10) based on the degree of cognitive impairment, while 17 healthy individuals without cognitive impairment were recruited as control group. MR examination and 18F-florbutaben (18F-FBB) PET imaging were performed, the cortical thickness and Aβ deposition value (Centiloid [CL] value) were calculated and compared among 3 groups and between each 2 groups, then the correlation between the above two indexes was analyzed. Results The cortical thickness in dementia group, MCI group and control group was (2.18±0.14), (2.35±0.08) and (2.36±0.09) mm, respectively, with significant difference among 3 groups (P＜0.05). The cortical thickness in dementia group was significantly thinner than that in MCI group and control group (both P＜0.05). CL value in dementia group, MCI group and control group was 77.97 (63.07, 95.55), 65.51 (54.54, 90.50) and －1.17 (－9.66, 4.88), respectively, with significant difference among 3 groups (P＜0.05). CL value in dementia group and MCI group were significantly higher than in control group (both P＜0.05). The cortical thickness was moderately negatively correlated with CL value in MCI group (r=－0.580, P=0.048) but not in the other 2 groups (both P＞0.05). Conclusion The cortical thickness was moderately negatively correlated with abnormal deposition of Aβ in patients with AD induced MCI, but was not during dementia. |
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