| 朱胤琰,张焱,黄干,辛玫,袁沛哲,王悦,万良荣,王成,黄钢,刘建军,张晨鹏.基于FDG PET/MR分析阿尔茨海默病患者不同脑区占全脑百分比与脑代谢的相关性[J].中国医学影像技术,2025,41(2):203~206 |
| 基于FDG PET/MR分析阿尔茨海默病患者不同脑区占全脑百分比与脑代谢的相关性 |
| Analyzing correlations of volume percentage and metabolism of brain region in patients with Alzheimer disease based on FDG PET/MR |
| 投稿时间：2024-09-09 修订日期：2025-01-18 |
| DOI：10.13929/j.issn.1003-3289.2025.02.005 |
| 中文关键词: 阿尔茨海默病 正电子发射断层显像术 磁共振成像 |
| 英文关键词:Alzheimer disease positron-emission tomography magnetic resonance imaging |
| 基金项目:上海市分子影像学重点实验室建设项目(18DZ2260400)。 |
| 作者 | 单位 | E-mail | | 朱胤琰 | 上海交通大学医学院附属仁济医院核医学科, 上海 200127 | | | 张焱 | 上海交通大学医学院附属仁济医院核医学科, 上海 200127 | | | 黄干 | 上海交通大学医学院附属仁济医院核医学科, 上海 200127 | | | 辛玫 | 上海交通大学医学院附属仁济医院核医学科, 上海 200127 | | | 袁沛哲 | 上海交通大学医学院附属仁济医院核医学科, 上海 200127 | | | 王悦 | 上海交通大学医学院附属仁济医院核医学科, 上海 200127 | | | 万良荣 | 上海交通大学医学院附属仁济医院核医学科, 上海 200127 | | | 王成 | 上海交通大学医学院附属仁济医院核医学科, 上海 200127 | | | 黄钢 | 上海交通大学医学院附属仁济医院核医学科, 上海 200127
上海市分子影像学重点实验室, 上海健康医学院, 上海 201318 | | | 刘建军 | 上海交通大学医学院附属仁济医院核医学科, 上海 200127 | | | 张晨鹏 | 上海交通大学医学院附属仁济医院核医学科, 上海 200127 | zhangchenpeng1981@126.com |
|
| 摘要点击次数: 403 |
| 全文下载次数: 106 |
| 中文摘要: |
| 目的 基于18F-FDG PET/MR脑显像分析阿尔茨海默病(AD)患者大脑特定脑区体积在全脑体积中所占百分比(记为占比%)与标准摄取值(SUV)之间,以及二者变化之间的相关性。方法 回顾性纳入50例AD患者,基于脑18F-FDG PET/MR图像获取40个特定脑区体积,计算占比%及平均SUV(SUVmean),分析各脑区占比%与其SUVmean的相关性;以基于正常大脑的数据库为参照,计算AD患者各脑区占比%的Z值及SUVmean的Z值,分别以之代表脑区结构与功能变化,观察二者相关性。结果 29个脑区占比%与SUVmean原始值之间,以及占比%与SUVmean的Z值之间均具有相关性(r=0.288~0.778,P均＜0.05),其中双侧颞中回、右侧梭状回、右侧海马、右侧楔前叶、左侧舌回及右侧海马旁回共7个脑区的相关系数均＞0.6。结论 FDG PET/MR所示AD患者大脑结构与代谢功能,以及二者改变之间均存在相关性。 |
| 英文摘要: |
| Objective To investigate correlations of the ratio of specific brain region volume to total brain volume (ratio%), standard uptake value (SUV) of specific brain region based on 18F-FDG PET/MR examination in Alzheimer disease (AD) patients, as well as the relationship between changes of these two. Methods Fifty AD patients were retrospectively collected. Based on FDG PET/MR, the ratio% and the mean SUV (SUVmean) of 40 specific brain regions were obtained, and the correlation between ratio% and SUVmean for each region were evaluated. According to a database of normal brains, Z-scores for ratio% and SUVmean were calculated to represent structural and functional changes in AD patients, and the correlation between these 2 Z-scores was assessed. Results Correlations were found between ratio% and SUVmean, also between Z-scores of these two parameters in 29 brain regions (r=0.288 to 0.778, all P＜0.05). Among them 7 brain regions, i.e. bilateral middle temporal gyrus, right fusiform gyrus, right hippocampus, right precuneus, left lingual gyrus and right parahippocampal gyrus exhibited correlation coefficients greater than 0.6. Conclusion There were some relationships between brain structural and metabolic functions and their changes in AD patients showed on FDG PET/MR. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
