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2025-06-13 星期五
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李霜,闫少珍,路伟钊,宋天彬,杨畅,张春,卢洁.早期帕金森病患者脑葡萄糖代谢异常与纹状体多巴胺能神经元受损的相关性[J].中国医学影像技术,2025,41(1):35~39

早期帕金森病患者脑葡萄糖代谢异常与纹状体多巴胺能神经元受损的相关性

Correlation between brain abnormal glucose metabolism and striatal dopaminergic neuron damage in early-stage Parkinson disease patients

投稿时间：2024-08-14 修订日期：2024-12-23

DOI：10.13929/j.issn.1003-3289.2025.01.008

中文关键词: 帕金森病脑正电子发射断层显像前瞻性研究

英文关键词:Parkinson disease brain positron-emission tomography prospective studies

基金项目:国家重点研发计划(2022YFC2406900)。

作者	单位	E-mail
李霜	湖北医药学院附属襄阳市第一人民医院核医学科, 湖北襄阳 441000 首都医科大学宣武医院放射与核医学科, 北京 100053 磁共振成像脑信息学北京市重点实验室, 北京 100053
闫少珍	首都医科大学宣武医院放射与核医学科, 北京 100053 磁共振成像脑信息学北京市重点实验室, 北京 100053
路伟钊	首都医科大学宣武医院放射与核医学科, 北京 100053 磁共振成像脑信息学北京市重点实验室, 北京 100053
宋天彬	首都医科大学宣武医院放射与核医学科, 北京 100053 磁共振成像脑信息学北京市重点实验室, 北京 100053
杨畅	首都医科大学宣武医院放射与核医学科, 北京 100053 磁共振成像脑信息学北京市重点实验室, 北京 100053
张春	首都医科大学宣武医院放射与核医学科, 北京 100053 磁共振成像脑信息学北京市重点实验室, 北京 100053
卢洁	首都医科大学宣武医院放射与核医学科, 北京 100053 磁共振成像脑信息学北京市重点实验室, 北京 100053	imaginglu@hotmail.com

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中文摘要:

目的观察早期帕金森病(PD)患者脑葡萄糖代谢异常与纹状体多巴胺能神经元受损的相关性。方法前瞻性对32例早期PD患者(PD组)及18名健康人(对照组)行¹⁸F-FDG及¹⁸F-二氢丁苯那嗪(¹⁸F-FP-DTBZ)PET/MR脑显像;比较组间摄取程度,分析脑葡萄糖代谢异常与纹状体多巴胺能神经元受损的相关性。结果相比对照组,¹⁸F-FDG PET示PD组双侧额叶及顶叶葡萄糖代谢减低(P均＜0.05)而双侧壳核、脑桥和双侧小脑葡萄糖代谢增高(P均＜0.05);¹⁸F-FP-DTBZ PET示PD组双侧尾状核、前壳核及后壳核摄取均明显减低(P均＜0.05)。PD组壳核平均标准摄取值(SUV_mean)与对侧尾状核标准摄取值比值(SUVR)呈正相关(r=0.305,P=0.014),额叶皮层SUV_mean与对侧和症状侧尾状核(r=0.352、0.324)及前壳核(r=0.300、0.314)SUVR均呈正相关(P均＜0.05),顶叶局部皮层SUV_mean与对侧和症状侧尾状核、对侧前壳核SUVR呈正相关(r=0.329、0.303、0.330,P均＜0.05)。结论早期PD患者脑葡萄糖代谢异常与纹状体多巴胺能神经元受损存在一定相关性。

英文摘要:

Objective To observe the correlation between brain abnormal glucose metabolism and striatal dopaminergic neuron damage in early-stage Parkinson disease (PD) patients. Methods Thirty-two early-stage PD patients (PD group) and 18 healthy individuals (control group) were prospectively enrolled, and ¹⁸F-FDG and ¹⁸F-9-fluoropropyl-(+)-dihydrotetrabenazine (¹⁸F-FP-DTBZ) PET/MR brain imaging were performed. The degrees of uptake were compared between groups, and the correlation between brain abnormal glucose metabolism and striatal dopaminergic neuron damage was analyzed. Results Compared with control group, ¹⁸F-FDG PET showed that in PD group glucose metabolism decreased in bilateral frontal and parietal lobes but increased in bilateral putamen, pons and bilateral cerebellum (all P＜0.05), while¹⁸F-FP-DTBZ PET showed that in PD group glucose metabolism decreased in bilateral caudate nucleus, anterior putamen and posterior putamen (all P＜0.05). In PD group, the mean standard uptake value (SUV_mean) of putamen was positively correlated with the standard uptake value ratio (SUVR) of contralateral caudate nucleus (r=0.305, P=0.014), while SUV_mean of frontal cortex was positively correlated with SUVR of contralateral and symptomatic caudate nucleus (r=0.352, 0.324, both P＜0.05) as well as anterior putamen (r=0.300, 0.314, both P＜0.05), SUV_mean of the partial cortex in parietal lobe was positively correlated with SUVR of contralateral and symptomatic caudate nucleus and contralateral anterior putamen (r=0.329, 0.303, 0.330, all P＜0.05). Conclusion Brain abnormal glucose metabolism had certain correlation with striatal dopaminergic neuron damage in early-stage PD patients.

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