| 黄卓,朱文晖.基于微纳米泡超声显像及治疗策略进展[J].中国医学影像技术,2024,40(12):1941~1944 |
| 基于微纳米泡超声显像及治疗策略进展 |
| Progresses of micro-nano bubbles based ultrasound imaging and treatment strategies |
| 投稿时间：2024-04-19 修订日期：2024-08-10 |
| DOI：10.13929/j.issn.1003-3289.2024.12.028 |
| 中文关键词: 超声检查 造影剂 微气泡 遗传学技术 |
| 英文关键词:ultrasonography contrast media microbubbles genetic techniques |
| 基金项目: |
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| 中文摘要: |
| 利用微纳米泡(MNB)进行超声检查不仅能获得常规对比显像,还可实现靶向分子成像。MNB在声场中空化和破裂可影响周围细胞膜通透性及内环境,进而提高跨膜、跨屏障转运效率,改变肿瘤免疫微环境。在预定部位施加超声场后,MNB的爆破力可推进所携物质靶向跨膜转运,实现细胞水平靶向干预,减少脱靶效应。生物合成气体囊泡及声学报告基因使生物体主动显影及细胞功能监测成为可能。MNB基于声辐射力的细胞声学操纵可用于细胞富集或特定空间排列等用途。本文就基于MNB超声显像及治疗策略进展进行综述。 |
| 英文摘要: |
| Ultrasound based on micro-nano bubbles (MNB) enables not only conventional contrast imaging but also targeted molecular imaging. The cavitation and collapse of MNB in the acoustic field will affect the permeability of surrounding cell membrane and the internal environment, hence improving transport efficiency through transmembrane and barrier and impacting tumor immune microenvironment. After applying an ultrasound field at a predetermined site, MNB collapse force could promote the targeted transmembrane transport of the carrying material, enable targeted intervention at the cellular level and reduce off-target effects. The biosynthetic gas vesicles and acoustic reporter genes have made active imaging in vivo and monitor cell function possible. Acoustic manipulation of MNB based on acoustic radiation forces had been applied in cell enrichment or specific spatial arrangement. The progresses of MNB based ultrasound imaging and treatment strategies were reviewed in this article. |
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