| 李天悦,马拓,赵新明,张召奇,王建方,戴萌,赵秀娟,张敬勉.68Ga-FAPI PET/CT及PET/MR诊断恶性肿瘤研究进展[J].中国医学影像技术,2024,40(11):1794~1797 |
| 68Ga-FAPI PET/CT及PET/MR诊断恶性肿瘤研究进展 |
| Research progresses of 68Ga-FAPI PET/CT and PET/MR for diagnosing malignant tumors |
| 投稿时间：2024-02-01 修订日期：2024-05-23 |
| DOI：10.13929/j.issn.1003-3289.2024.11.033 |
| 中文关键词: 肿瘤 镓放射性同位素 正电子发射断层显像术 体层摄影术,X线计算机 磁共振成像 |
| 英文关键词:neoplasms gallium radioisotopes positron-emission tomography tomography, X-ray computed magnetic resonance imaging |
| 基金项目:河北省自然科学基金面上项目(H2023206016)、河北省2024年度卫生健康委医学科学研究课题计划(20240289)。 |
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| 中文摘要: |
| 成纤维细胞激活蛋白抑制剂(FAPI)可与肿瘤间质内高表达的成纤维细胞激活蛋白特异性结合;68Ga-FAPI不参与肿瘤细胞葡萄糖代谢。68Ga-FAPI PET/CT及PET/MR可用于多部位恶性肿瘤显像,对于诊断与鉴别诊断具有独特优势。本文围绕68Ga-FAPI PET/CT及PET/MR诊断恶性肿瘤研究进展进行综述。 |
| 英文摘要: |
| Fibroblast activation protein inhibitors (FAPI) can specifically bind to fibroblast activation protein, which is highly expressed in tumor stroma, and 68Ga-FAPI do not get involved into the procedure of glucose metabolism in tumor cells. 68Ga-FAPI PET/CT and PET/MR can be used for displaying malignant tumors at various sites and play a unique role for diagnosis and differential diagnosis. The research progresses of 68Ga-FAPI-based PET/CT and PET/MR for diagnosing malignant tumors were reviewed in this article. |
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