| 孟帆,袁军辉,张孝先,方少伯,郭兰伟,单东秋,陈学军.全肿瘤表观弥散系数直方图鉴别腺泡状软组织肉瘤组织学级别[J].中国医学影像技术,2024,40(11):1754~1759 |
| 全肿瘤表观弥散系数直方图鉴别腺泡状软组织肉瘤组织学级别 |
| Whole-tumor apparent diffusion coefficient histogram for identifying histological grade of alveolar soft part sarcoma |
| 投稿时间：2024-05-22 修订日期：2024-07-15 |
| DOI：10.13929/j.issn.1003-3289.2024.11.025 |
| 中文关键词: 肉瘤,软组织腺泡状 间变 磁共振成像 |
| 英文关键词:sarcoma, alveolar soft part anaplasia magnetic resonance imaging |
| 基金项目: |
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| 中文摘要: |
| 目的 观察全肿瘤表观弥散系数(ADC)直方图鉴别腺泡状软组织肉瘤(ASPS)病理组织学级别的价值。方法 回顾性分析43例ASPS、包括高级别组27例和低级别组16例,记录患者生存资料,分析肿瘤MRI表现,获取全肿瘤ADC直方图参数并进行组间比较,评估组间差异有统计学意义参数与组织学分级结果的相关性,评估其鉴别高、低级别ASPS的效能。结果 低级别组患者5年生存率为82.05%,高于高级别组的51.28%(P＜0.05)。与低级别组相比,高级别组远处转移、ASPS肿瘤≥5 cm,以及伴瘤周水肿、肿瘤内分隔等特征者占比均较高(P均＜0.05)。全肿瘤ADC直方图参数中,高级别组5th、10th、25th、50th、75th、90th及均值均低于低级别组(P均＜0.05),且均与肿瘤病理组织学分级呈负相关(－0.547~－0.385,P均＜0.05),其鉴别高、低组织学分级ASPS的受试者工作特征曲线下面积为0.734~0.822,鉴别效能均较好。结论 全肿瘤ADC直方图参数可较为有效地鉴别高、低级别ASPS。 |
| 英文摘要: |
| Objective To observe the value of whole-tumor apparent diffusion coefficient (ADC) histogram for identifying histopathological grade of alveolar soft part sarcoma (ASPS). Methods Forty-three ASPS patients,including 27 cases of high-grade ASPS (high-grade group) and 16 cases of low-grade ASPS (low-grade group) were retrospectively enrolled. Patients' survival data were collected, MRI manifestations of ASPS were recorded, and the whole-tumor ADC histogram parameters were obtained and compared between groups. The correlations of whole-tumor ADC histogram parameters being different between groups with tumors' histological grading were analyzed, and the efficacy of whole-tumor ADC histogram parameters for identifying high-grade and low-grade ASPS were assessed. Results The 5-year survival rate of ASPS patients in low-grade group was 82.05%, higher than that (51.28%) in high-grade group (P＜0.05). The percentage of distant metastasis, tumor≥5 cm, as well as of tumors with features such as peritumoral edema and intra-tumoral septum in high-grade group were all higher than in low-grade group (all P＜0.05). The 5th, 10th, 25th, 50th, 75th, 90th and the mean values of ADC in high-grade group were all lower than those in low-grade group (all P＜0.05) and negatively correlated with pathohistological grade of ASPS (from －0.547 to －0.385, all P＜0.05). The aeras under the receiver operating characteristic curves of the above parameters ranged from 0.734 to 0.822, which were fairly good for identifying high-grade and low-grade ASPS. Conclusion Whole-tumor ADC histogram parameters could be used to effectively identify high-grade and low-grade ASPS. |
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