| 彭湃,苟心怡,李田园,张秀英,程瑾.多参数定量MRI诊断甲状腺相关眼病合并甲状腺功能障碍性视神经病变[J].中国医学影像技术,2024,40(11):1667~1671 |
| 多参数定量MRI诊断甲状腺相关眼病合并甲状腺功能障碍性视神经病变 |
| Multiparametric quantitative MRI for diagnosis of thyroid-associated ophthalmopathy complicated with dysthyroid optic neuropathy |
| 投稿时间：2024-05-07 修订日期：2024-08-16 |
| DOI：10.13929/j.issn.1003-3289.2024.11.008 |
| 中文关键词: 眼 视神经 甲状腺 磁共振成像 |
| 英文关键词:eye optic nerve thyroid gland magnetic resonance imaging |
| 基金项目: |
|
| 摘要点击次数: 440 |
| 全文下载次数: 97 |
| 中文摘要: |
| 目的 观察多参数定量MRI诊断甲状腺相关眼病(TAO)合并甲状腺功能障碍性视神经病变(DON)的价值。方法 回顾性纳入55例TAO患者、共109只患眼,根据是否伴DON分为DON组(22例共44只患眼)与非DON组(33例共65只患眼)。比较组间临床资料及多参数定量MRI指标,以logistic回归筛选TAO合并DON的影响因素并建立模型,观察其诊断效能。结果 组间病程、眼球突出程度、肌肉指数,以及增粗眼外肌数量、厚度、T1值、T2值、脂肪分数和眶内脂肪水分数差异均有统计学意义(P均＜0.05)。增粗眼外肌T1值及眶内脂肪水分数为TAO合并DON的独立影响因素,以之诊断TAO合并DON的曲线下面积(AUC)分别为0.859和0.868,二者联合诊断的AUC为0.922,显著大于单一眶内脂肪水分数(P=0.034)而与单一T1值差异无统计学意义(P=0.851)。结论 基于多参数定量MRI增粗眼外肌T1值及眶内脂肪水分数有助于诊断TAO合并DON。 |
| 英文摘要: |
| Objective To observe the value of multiparametric quantitative MRI for diagnosis of thyroid-associated ophthalmopathy (TAO) complicated with dysthyroid optic neuropathy (DON). Methods Fifty-five TAO patients with 109 affected eyes were retrospectively enrolled and divided into DON group (22 cases with 44 affected eyes) and non DON group (33 cases with 65 affected eyes) based on complicated with DON or not. Clinical data and multiparametric quantitative MRI indicators were compared between groups. The influencing factors of TAO complicated with DON were screened with logistic regression to establish a model, and the diagnostic efficacy of the model was observed. Results Significant differences of the course of disease, degree of eyeball protrusion, muscle index, as well as the number, thickness, T1 value, T2 value, fat fraction and orbital fat water fraction of thickened extraocular muscle were found between groups (all P＜0.05). T1 value and orbital fat water fraction of thickened extraocular muscle were both independent influencing factors of TAO complicated with DON, with the area under the curve (AUC) for diagnosing TAO complicated with DON of 0.859 and 0.868, respectively, and AUC of the combined diagnosis of the two was 0.922, significantly higher than orbital fat water fraction alone (P=0.034) but not significantly different with that of T1 value alone (P=0.851). Conclusion T1 value and orbital fat water fraction of thickened extraocular muscle based on multiparametric quantitative MRI were helpful for diagnosing TAO complicated with DON. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
