| 冉瑶,徐佳虹,史新旺,刘依静,蔡德佳,周小伟.宽波束谐波运动成像定位高强度聚焦超声治疗焦点:体外研究[J].中国医学影像技术,2024,40(11):1655~1660 |
| 宽波束谐波运动成像定位高强度聚焦超声治疗焦点:体外研究 |
| Wide beam-harmonic motion imaging for locating focus of high intensity focused ultrasound: An in vitro study |
| 投稿时间：2024-06-11 修订日期：2024-08-28 |
| DOI：10.13929/j.issn.1003-3289.2024.11.006 |
| 中文关键词: 体外冲击波疗法 谐波运动成像 宽波束成像 |
| 英文关键词:extracorporeal shockwave therapy harmonic motion imaging wide beam imaging |
| 基金项目:国家自然科学基金项目(12304508)、重庆市自然科学基金(CSTB2022NSCQ-MSX0968)。 |
| 作者 | 单位 | E-mail | | 冉瑶 | 重庆医科大学生物医学工程学院, 超声医学工程国家重点实验室, 重庆 400016 | | | 徐佳虹 | 重庆医科大学生物医学工程学院, 超声医学工程国家重点实验室, 重庆 400016 | | | 史新旺 | 重庆医科大学生物医学工程学院, 超声医学工程国家重点实验室, 重庆 400016 | | | 刘依静 | 重庆医科大学生物医学工程学院, 超声医学工程国家重点实验室, 重庆 400016 | | | 蔡德佳 | 重庆医科大学生物医学工程学院, 超声医学工程国家重点实验室, 重庆 400016 | | | 周小伟 | 重庆医科大学生物医学工程学院, 超声医学工程国家重点实验室, 重庆 400016 | zhou.xiaowei@cqmu.edu.cn |
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| 中文摘要: |
| 目的 观察超声宽波束(WB)谐波运动成像(HMI)(WB-HMI)用于定位离体组织高强度聚焦超声(HIFU)辐照焦点的有效性。方法 开发以声辐射力和超声成像为关键的WB-HMI技术。针对离体猪里脊和牛肝组织,采用不同幅度调制(AM)频率(25~100 Hz)和激励声功率(0.7~28 W)实现WB-HMI、定位HIFU辐照焦点,观察不同参数组合下WB-HMI定位辐照焦点的差异;以HIFU后声像图中的实际焦点位置为标准,以焦点定位误差＜1 mm为WB-HMI定位焦点有效的标准,计算定位成功率。结果 相同AM频率下,声功率越大,WB-HMI定位焦点的位移幅值越大;相同声功率激励下,AM频率越小,WB-HMI定位焦点的位移幅值越大。对于离体猪里脊组织,不同AM频率下,声功率为15 W或22 W时,WB-HMI定位HIFU辐射焦点成功率均高于90.00%,而声功率为28 W时,定位成功率呈降低趋势;对于离体牛肝组织,声功率≥7.0 W时,WB-HMI定位成功率达100%。结论 WB-HMI能有效定位HIFU辐照离体组织焦点。 |
| 英文摘要: |
| Objective To observe the effectiveness of ultrasound wide beam (WB)-based harmonic motion imaging (HMI) (WB-HMI) for locating irradiation focus of high intensity focused ultrasound (HIFU) for in vitro tissue. Methods WB-HMI technology was developed with acoustic radiation force and ultrasound imaging as the key technology. For in vitro porcine tenderloin and bovine liver tissue,different amplitude modulation (AM) frequencies (25—100 Hz) and excitation acoustic power (0.7—28 W) were used to achieve WB-HMI localization of HIFU irradiation focus, and the differences of WB-HMI localization of HIFU irradiation focus under different parameter combinations were observed. Taken the actual focus position on ultrasonic image after HIFU as the standard and the focus positioning error＜1 mm as the effective standard of WB-HMI locating irradiation focus, the locating success rate was calculated. Results The larger the acoustic power, the larger the displacement amplitude of irradiation focus by WB-HMI at the same AM frequency, while the smaller the AM frequency, the larger the displacement amplitude of irradiation focus located by WB-HMI under the same acoustic power. Under different AM frequencies, for in vitro porcine tenderloin, the success rate of WB-HMI for locating HIFU radiation focus was higher than 90.00% when acoustic power was 15 W or 22 W, whereas the success rate showed a decreasing trend when the acoustic power was 28 W. For in vitro bovine liver tissue, the success rate of WB-HMI localization was 100% when acoustic power was ≥7.0 W. Conclusion WB-HMI could be used to effectively locate HIFU irradiation focus for isolated tissue. |
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