| 李莹,程敬亮,任翠萍,张勇,张文华,林良杰.3D氨基质子转移加权成像联合弥散加权成像鉴别良、恶性骨与软组织肿瘤[J].中国医学影像技术,2024,40(10):1572~1576 |
| 3D氨基质子转移加权成像联合弥散加权成像鉴别良、恶性骨与软组织肿瘤 |
| 3D amide proton transfer weighted imaging combined with diffusion weighted imaging for differentiating benign and malignant bone and soft tissue tumors |
| 投稿时间：2024-04-01 修订日期：2024-06-14 |
| DOI：10.13929/j.issn.1003-3289.2024.10.024 |
| 中文关键词: 骨肿瘤 软组织肿瘤 磁共振成像 氨基质子转移 前瞻性研究 |
| 英文关键词:bone neoplasms soft tissue neoplasms magnetic resonance imaging amide proton transfer prospective studies |
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| 中文摘要: |
| 目的 探讨3D氨基质子转移加权成像(APTWI)、弥散加权成像(DWI)及二者联合鉴别良、恶性骨与软组织肿瘤的价值。方法 前瞻性对96例骨盆或下肢骨与软组织肿瘤患者采集平扫MRI、APTWI及DWI。分别基于APTWI及DWI获得偏移量为3.5 ppm的非对称性磁化传递率(MTRasym)图及表观弥散系数(ADC)图,测量病灶MTRasym(3.5 ppm)最大值(MTRasymmax)、均值(MTRasymmean)及最小值(MTRasymmin),以及ADC最大值(ADCmax)、均值(ADCmean)及最小值(ADCmin);比较良、恶性肿瘤各参数差异,绘制受试者工作特征曲线,计算曲线下面积(AUC),评估APTWI、DWI及二者联合的鉴别诊断效能。结果 96例中,良性41例、恶性55例。恶性肿瘤MTRasym(MTRasymmax、MTRasymmean和MTRasymmin)均明显高于,而ADC(ADCmax、ADCmean和ADCmin)均明显低于良性肿瘤(P均＜0.05)。MTRasymmax和ADCmin鉴别良、恶性肿瘤的AUC分别为0.791和0.873,差异无统计学意义(P=0.122);二者联合的AUC为0.944,高于单一项(P＜0.001、P=0.041)。结论 APTWI联合DWI鉴别良、恶性骨与软组织肿瘤的效能较高。 |
| 英文摘要: |
| Objective To explore the value of 3D amide proton transfer weighted imaging (APTWI), diffusion weighted imaging (DWI) and the combination for differentiating benign and malignant bone and soft tissue tumors. Methods Non-contrast MRI, APTWI and DWI of pelvis or lower extremity were prospectively acquired in 96 patients with bone and soft tissue tumors. MTRasym and ADC maps were obtained based on APTWI and DWI calculation with an offset of 3.5 ppm, respectively, and the maximum asymmetric magnetization transfer rate (MTRasym) (MTRasymmax), the mean MTRasym (MTRasymmean) and the minimum MTRasym (MTRasymmin), as well as the maximum apparent diffusion coefficient (ADC) (ADCmax), the mean ADC (ADCmean) and the minimum ADC (ADCmin) values were measured. The above parameters were compared between benign and malignant tumors. Then receiver operating characteristic curve was drawn, and the area under the curve (AUC) was calculated to evaluate the efficacy of APTWI, DWI and the combination. Results Among 96 patients, there were 41 benign and 55 malignant pelvic or lower limb bone and soft tissue tumors. In benign tumors, MTRasym (3.5 ppm) values, including MTRasymmax, MTRasymmean and MTRasymmin were significantly higher, whereas ADC values including ADCmax, ADCmean and ADCmin were significantly lower than those in malignant tumors (all P＜0.05). AUC of MTRasymmax and ADCmin for differentiating benign and malignant bone and soft tissue tumors was 0.791 and 0.873, respectively, being not statistically different (P=0.122), but both lower than that of their combination (AUC=0.944, P＜0.001, P=0.041). Conclusion APTWI combined with DWI had high efficacy for differentiating benign and malignant bone and soft tissue tumors. |
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