| 钟丽婷,游瑞雄,林诗茜,陈琦.伪连续式动脉自旋标记MRI评估肾脏占位患者肾功能[J].中国医学影像技术,2024,40(10):1557~1561 |
| 伪连续式动脉自旋标记MRI评估肾脏占位患者肾功能 |
| Pseudo-continuous arterial spin labeling MRI for evaluating renal function in patients with renal occupying lesions |
| 投稿时间：2024-04-08 修订日期：2024-08-29 |
| DOI：10.13929/j.issn.1003-3289.2024.10.021 |
| 中文关键词: 肾肿瘤 肾功能不全 磁共振成像 动脉自旋标记 |
| 英文关键词:kidney neoplasms renal insufficiency magnetic resonance imaging arterial spin labeling |
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| 中文摘要: |
| 目的 观察伪连续式动脉自旋标记(PCASL)MRI评估肾脏占位患者肾功能的价值。方法 回顾性分析56例单发肾脏占位患者,根据99Tcm-DTPA肾动态显像测得肾小球滤过率(GFR)分别将左、右侧肾脏分为肾功能正常组(正常组,≥30 ml/min)及肾功能损伤组(异常组,＜30 ml/min);分别采用全肾测量法及肾皮质测量法基于PCASL MRI计算双侧肾血流量(tRBF、cRBF),比较同侧正常组与异常组GFR、tRBF及cRBF;绘制受试者工作特征曲线,计算曲线下面积(AUC),分析tRBF及cRBF评估单侧肾功能损伤的效能;以Pearson相关分析观察tRBF及cRBF与GFR的相关性。结果 左/右侧损伤组GFR、tRBF及cRBF均显著低于各自同侧正常组(P均＜0.05)。tRBF及cRBF评估左肾功能损伤的AUC分别为0.823及0.813,评估右肾功能损伤的AUC分别为0.940及0.922,差异均无统计学意义(P＞0.05)。双肾tRBF及cRBF值与GFR均无明显相关(P均＞0.05)。结论 PCASL MRI可有效评估肾脏占位患者肾功能;基于全肾测量法与肾皮质测量法所获效能相当。 |
| 英文摘要: |
| Objective To observe the value of pseudo-continuous arterial spin labeling (PCASL) MRI for evaluating renal function in patients with renal occupying lesions. Methods Totally 56 patients with single renal occupying lesion were retrospectively enrolled. The left and right side kidneys were divided into normal renal function group (normal group, ≥30 ml/min) and damaged renal function group (damaged group, ＜30 ml/min) according to glomerular filtration rate (GFR) measured with 99Tcm-DTPA dynamic renal imaging, respectively. The total renal blood flow (tRBF) and cortical renal blood flow (cRBF) were calculated using total nephrometry and cortical nephrometry based on PCASL MRI, respectively, then GFR, tRBF and cRBF were compared between groups on the same side. Receiver operating characteristic curve was drawn, and the area under the curve (AUC) was calculated to evaluate the efficacy of tRBF and cRBF for assessing unilateral renal injury. Pearson correlation analysis was performed to observe the correlations of tRBF and cRBF with GFR. Results GFR, tRBF and cRBF in left/right damaged group were all significantly lower than those in ipsilateral normal group (all P＜0.05). AUC of tRBF and cRBF for assessing left renal injury was 0.823 and 0.813, respectively, being not significantly different (P＞0.05). AUC of tRBF and cRBF for assessing right renal injury was 0.940 and 0.922, respectively, being not significantly different (P＞0.05). No obvious correlation of bilateral tRBF nor cRBF with GFR was found (all P＞0.05). Conclusion PCASL MRI could effectively evaluate renal function in patients with renal occupying lesion, and the efficacy of total nephrometry was comparable to that of cortical nephrometry. |
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