| 贺俊景,周丽格,孙杰梅,沈智威,张刚,邢威.酰胺质子转移成像及MR波谱技术评估稳定期慢性阻塞性肺疾病中枢神经系统损伤[J].中国医学影像技术,2024,40(10):1481~1486 |
| 酰胺质子转移成像及MR波谱技术评估稳定期慢性阻塞性肺疾病中枢神经系统损伤 |
| Amide proton transfer imaging and MR spectroscopy for assessing central nervous system damages in stable chronic obstructive pulmonary disease |
| 投稿时间：2024-03-23 修订日期：2024-07-02 |
| DOI：10.13929/j.issn.1003-3289.2024.10.006 |
| 中文关键词: 肺疾病,慢性阻塞性 中枢神经系统 磁共振成像 磁共振波谱 呼吸功能试验 |
| 英文关键词:pulmonary disease,chronic obstructive central nervous system magnetic resonance imaging magnetic resonance spectroscopy respiratory function tests |
| 基金项目:河南省科技攻关项目(232102310123)。 |
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| 中文摘要: |
| 目的 观察酰胺质子转移(APT)成像评估稳定期慢性阻塞性肺疾病(COPD)中枢神经系统损伤的价值及其与MR波谱(MRS)及肺功能参数的相关性。方法 前瞻性纳入39例稳定期COPD患者(COPD组)及34名健康人(对照组),行头颅平扫MR、3D-APT及丘脑MRS并检测肺功能;比较组间一般资料、基于体素的形态学(VBM)分析结果、多脑区APT值及丘脑MRS代谢物测值,分析APT值与丘脑MRS代谢物及肺功能参数的相关性。结果 COPD组肺功能测值均低于对照组,而脑脊液体积(CSFV)及全脑体积(TIV)均较对照组增大(P均＜0.05)。相比对照组,COPD组双侧丘脑、右颞叶及右枕叶APT值均升高,双侧丘脑N-乙酰天冬氨酸(NAA)峰值及右丘脑NAA/肌酸数值均降低(P均＜0.05)。COPD组内双侧丘脑APT值呈正相关(r=0.641),左丘脑APT与NAA值(r=－0.435)及予支气管舒张剂后第1秒用力呼气容积(FEV1,r=－0.432)均呈负相关(P均＜0.05)。结论 COPD患者中枢神经系统APT升高而NAA降低,且左丘脑APT与NAA及FEV1均呈负相关。 |
| 英文摘要: |
| Objective To observe the value of amide proton transfer (APT) imaging for assessing central nervous system damages in stable chronic obstructive pulmonary disease (COPD) and the correlations with MR spectroscopy (MRS) and lung function parameters. Methods Thirty-nine stable COPD patients (COPD group) and 34 healthy subjects (control group) were prospectively enrolled. Images of plain head MR, 3D-APT and thalami MRS were acquired, and parameters of lung function were obtained. The basic data, outcomes of voxel-based morphometry (VBM) analysis, APT values in multiple brain regions and thalami MRS metabolite parameters were compared between groups, and the correlations of thalamus APT values with thalamus MRS metabolites parameters and lung function parameters were explored. Results Lung function parameters in COPD group were lower than those in control group, while cerebrospinal fluid volume (CSFV) and total brain volume (TIV) in COPD group were lager than those in control group (all P＜0.05). Compared with those in control group, APT values of bilateral thalami, right temporal lobe and right occipital lobe in COPD group were higher, and the peak value of N-acetyl aspartate (NAA) of bilateral thalami and NAA/creatin of right thalamus in COPD group were lower (all P＜0.05). Within COPD group, APT values of bilateral thalami were positively correlated (r=0.641), while APT values of left thalamus showed negative correlation (r=－0.435) with NAA values left thalamus and negative correlation (r=－0.432) with the forced expiratory volume in the first one second after bronchodilator administration (FEV1) (all P＜0.05). Conclusion APT values of central nervous system elevated and NAA values decreased in COPD patients. There were negative correlations between left thalamus APT and NAA values, also between APT values of left thalamus and FEV1. |
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