| 张爱娟,陈基明,李周丽,吴莉莉,闫娜.年龄及月经状态对健康女性乳腺动态增强MRI半定量参数的影响[J].中国医学影像技术,2024,40(9):1336~1340 |
| 年龄及月经状态对健康女性乳腺动态增强MRI半定量参数的影响 |
| Impact of age and menstrual status on semi-quantitative parameters of breast dynamic enhanced MRI in healthy women |
| 投稿时间：2023-06-06 修订日期：2024-05-23 |
| DOI：10.13929/j.issn.1003-3289.2024.09.013 |
| 中文关键词: 乳腺,人 年龄因素 月经 磁共振成像 |
| 英文关键词:mammary glands, human age factors menstruation magnetic resonance imaging |
| 基金项目:皖南医学院2022年度校中青年科研基金项目(WK2022F24)。 |
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| 中文摘要: |
| 目的 观察年龄及月经状态对健康女性乳腺动态增强MRI(DCE-MRI)半定量参数的影响。方法 回顾性收集283名因疑诊乳腺包块或乳腺不适而接受MR检查且经临床随访1年无乳腺肿瘤的成年女性;另前瞻性招募49名处于行经期的健康成年女性(行经期亚组)。根据年龄将上述332名受试者分为低龄组(n=107)、中龄组(n=114)及高龄组(n=111),同时根据是否绝经将其分为绝经组(n=112)与未绝经组(n=220,含行经期亚组49名、增殖期亚组77名及分泌期亚组94名)。比较组间、亚组间乳腺DCE-MRI半定量参数(ERmax,Slopemax),包括最大强化率(ERmax)和最大上升斜率(Slopemax)的差异及其变异程度。结果 高、低龄组间ERmax及Slopemax差异均有统计学意义(P均＜0.05),中龄组ERmax和Slopemax与低及高龄组差异均无统计学意义(P均＞0.05)。绝经组ERmax及Slopemax均低于未绝经组(P均＜0.05)。不同月经周期亚组之间DCE-MRI半定量参数总体差异均无统计学意义(P均＞0.05)。低、中及高龄组中,正常乳腺ERmax的变异系数(CV)分别为56.20%、44.02%及50.97%,Slopemax的CV分别为54.74%、81.78%及76.93%。绝经后及未绝经成年女性正常乳腺ERmax的CV分别为50.12%及46.02%,Slopemax的CV分别为72.84%及62.04%。各亚组间,ERmax及Slopemax在增殖期亚组的CV均最大(61.39%、82.54%),而在行月经期亚组的CV均最小(33.99%、42.33%)。结论 不同年龄及月经状态下健康女性乳腺DCE-MRI半定量参数存在差异,且个体间变异度较大。 |
| 英文摘要: |
| Objective To observe the impact of age and menstrual status on semi-quantitative parameters of breast dynamic enhanced MRI (DCE-MRI) in healthy adult women. Methods A total of 283 adult females who underwent MR examinations due to suspected breast mass or breast discomfort but no breast tumor was detected after 1 year's clinical follow-up were retrospectively collected. Meanwhile, 49 healthy adult female subjects in the menstrual period (menstruating subgroup) were prospectively recruited. All the above 332 subjects were divided into low age group (n=107), middle age group (n=114) and high age group (n=111) according to age, while into postmenopausal group (n=112) and premenopausal group (n=220, including 49 in menstruating subgroup, 77 in proliferating subgroup and 94 in secreting subgroup). DCE-MRI semi-quantitative parameters, including maximum enhancement rate (ERmax) and maximum slope of increasing (Slopemax) were compared among different groups and subgroups, and the variations were observed. Results Significant differences of ERmax and Slopemax were found between high and low age groups (both P＜0.05), while no significant difference of ERmax and Slopemax was found between middle and low age group, nor between middle and high age group (all P＞0.05). Both ERmax and Slopemax in postmenopausal group were lower than those in premenopausal group (both P＜0.05), while no significant difference of DCE-MRI semi-quantitative parameters was found among different menstrual cycle subgroups (all P＞0.05). The coefficient of variance (CV) of normal breast ERmax in low, middle and high age groups was 56.20%, 44.02% and 50.97%, respectively, of Slopemax was 54.74%, 81.78% and 76.93%, respectively. CV of normal breast ERmax was 50.12% and 46.02% in postmenopausal and premenopausal groups, respectively, while CV of Slopemax was 72.84% and 62.04%, respectively. Among different subgroups, CV of ERmax and Slopemax in proliferative period were both the largest (61.39%, 82.54%), which in menstrual period were both the smallest (33.99%, 42.33%). Conclusion Semi-quantitative parameters of breast DCE-MRI were different among healthy women of different age and menstrual status, and the individual variations were large. |
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