| 段欢芹,李琳钦,邱丽华.静息态功能MRI用于轻度认知功能障碍及阿尔茨海默病研究进展[J].中国医学影像技术,2024,40(8):1254~1257 |
| 静息态功能MRI用于轻度认知功能障碍及阿尔茨海默病研究进展 |
| Research progresses of resting-state functional MRI in mild cognitive impairment and Alzheimer's disease |
| 投稿时间：2024-01-17 修订日期：2024-04-10 |
| DOI：10.13929/j.issn.1003-3289.2024.08.030 |
| 中文关键词: 阿尔茨海默病 认知障碍 磁共振成像 |
| 英文关键词:Alzheimer disease cognition disorders magnetic resonance imaging |
| 基金项目:国家重点研发计划(2022YFC2009900、2022YFC2009901)、四川省卫生健康委员会科技项目(23LCYJ021)。 |
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| 中文摘要: |
| 阿尔茨海默病(AD)为常见神经退行性疾病,早期主要表现为认知能力下降;轻度认知功能障碍(MCI)是介于正常衰老与AD之间的过渡状态。近年来,静息态功能MRI(rs-fMRI)相关研究揭示了MCI及AD发生、发展过程可能与脑区自发活动及脑区间功能连接变化密切相关,而rs-fMRI可为特异性诊断及早期治疗MCI及AD提供重要参考。本文就rs-fMRI用于MCI及AD研究进展进行综述。 |
| 英文摘要: |
| Alzheimer's disease (AD) is a prevalent neurodegenerative disease characterized by cognitive decline in the early stage. Mild cognitive impairment (MCI) is considered as an intermediate stage between normal aging and AD. In recent years, studies related to resting-state functional MRI (rs-fMRI) indicated that the occurrence and development process of MCI and AD might be closely linked to spontaneous brain activity and alterations in functional connectivity among brain regions, and rs-fMRI could provide important reference for specific diagnosis and early treatment of MCI and AD. The research progresses of rs-fMRI for MCI and AD were reviewed in this article. |
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