| 刘杉峰,陆晓晨,田浩,吴辉群.基于冠状动脉CT血管造影0D-1D耦合模型与3D流固耦合模型显示冠状动脉狭窄血流动力学特征[J].中国医学影像技术,2024,40(8):1236~1241 |
| 基于冠状动脉CT血管造影0D-1D耦合模型与3D流固耦合模型显示冠状动脉狭窄血流动力学特征 |
| 0D-1D coupling model and 3D fluid-structure interaction model based on coronary CT angiography for displaying hemodynamic characteristics of coronary artery stenosis |
| 投稿时间：2023-10-26 修订日期：2024-04-07 |
| DOI：10.13929/j.issn.1003-3289.2024.08.027 |
| 中文关键词: 冠状动脉狭窄 血流动力学 冠状动脉造影 体层摄影术,X线计算机 |
| 英文关键词:coronary stenosis hemodynamics coronary angiography tomography, X-ray computed |
| 基金项目:南通市市级科技计划指令性项目(社会民生科技)(MS2023050)。 |
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| 中文摘要: |
| 目的 观察基于冠状动脉CT血管造影(CCTA)0D-1D耦合模型与3D流固耦合(FSI)模型显示冠状动脉狭窄血流动力学特征的价值。方法 基于1例冠心病左前降支(LAD)狭窄患者的CCTA数据建立0D-1D耦合模型和3D FSI模型,于1 s内每间隔0.01 s分别采集2种模型5个相应采样点(即采样点1~5)的力学参数数据,包括压力、血流速度及壁面剪切应力(WSS),以Spearman相关系数rs评估模型间的一致性。结果 构建0D-1D耦合模型和3D FSI模型分别用时0.033 min和704 min。2种模型显示的狭窄LAD内压力、血流速度及WSS分布基本一致,均为狭窄段及其近端压力较高而其远端压力值逐渐降低,狭窄近端血流较为匀速缓慢,而狭窄段流速加快且WSS明显增高;但相比3D FSI模型,0D-1D血管耦合模型的精细程度不足,且在显示血流速度时出现远端流线缺失。针对位于狭窄段的采样点2,2种模型所示压力未见明显一致性(P=0.118)但血流速度及WSS均呈强一致性(rs=0.730、0.807,P均＜0.05),而狭窄近端及远端(采样点1、3~5)压力、血流速度及WSS具有弱至中等一致性(rs=0.237~0.669,P均＜0.05)。结论 0D-1D耦合模型用于模拟LAD狭窄具有出色计算效率,可提供较为合理的结果;而3D FSI模型模拟局部细节和流线精度较高。 |
| 英文摘要: |
| Objective To observe value of 0D-1D coupling model and 3D fluid-structure interaction (FSI) model based on coronary CT angiography (CCTA) for displaying hemodynamic characteristics of coronary artery stenosis. Methods Based on CCTA data of the stenosed left anterior descending branch (LAD) in a patient with coronary heart disease, an 0D-1D coupling model and 3D FSI model were built, respectively. Then hemodynamic characteristic indexes, including the pressure, flow velocity and wall shear stress (WSS) were obtained in every 0.01 s during 1 s at 5 sampling points (i.e. sampling point 1—5) using these 2 models, respectively, and the consistencies of the results between models were evaluated with Spearman correlation coefficient rs. Results The time consuming for construction of 0D-1D coupling model and 3D FSI model was 0.033 min and 704 min, respectively. Both models showed basically distribution of the pressure, flow velocity and WSS of the stenosed LAD. For more details, the pressure at the stenosed segment of LAD and the proximal segment of stenosis were both higher, which gradually decreased at the distal segment of stenosis, and the flow velocity at the proximal segment of stenosis was in a relatively slow and uniform condition, with significantly increased flow velocity and WSS at the stenosed segment. Compared with 3D FSI model, 0D-1D vascular coupling model was relatively unrefined and lack of distal flow lines when displaying blood flow velocity. For sampling point 2 at the stenosed segment of LAD, no significant consistency for pressure between 2 models was found (P=0.118), but strong consistency for the flow velocity and WSS (rs=0.730, 0.807, both P＜0.05). The consistencies of pressure, flow velocity and WSS between 2 models at the proximal and distal segment of stenosis, i.e. 1, 3—5 sampling points were week to moderate (rs=0.237—0.669, all P＜0.05). Conclusion 0D-1D coupling model exhibited outstanding computational efficiency and might provide relatively reasonable results, while 3D FSI model showed higher accuracy for details and streamline when simulating LAD stenosis. |
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