| 任佑祥,凌文武,罗燕,杨蕗璐.超声造影预测肝细胞癌分化程度[J].中国医学影像技术,2024,40(8):1199~1203 |
| 超声造影预测肝细胞癌分化程度 |
| Contrast-enhanced ultrasound for predicting differentiation degree of hepatocellular carcinoma |
| 投稿时间：2024-01-21 修订日期：2024-02-13 |
| DOI：10.13929/j.issn.1003-3289.2024.08.019 |
| 中文关键词: 癌,肝细胞 超声检查 病理分化 |
| 英文关键词:carcinoma, hepatocellular ultrasonography pathological differentiation |
| 基金项目:四川省自然科学基金(2024NSFSC1779)。 |
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| 中文摘要: |
| 目的 观察超声造影(CEUS)预测肝细胞癌(HCC)分化程度的价值。方法 回顾性分析经术后病理证实的86例HCC患者,依据术后病理Edmondson-Steiner分级分为低、中及高分化组。比较组间术前CEUS参数差异,以二元logistic回归分析不同分化程度HCC的CEUS相关独立预测因素;针对差异有统计学意义的CEUS参数绘制受试者工作特征曲线,计算曲线下面积(AUC),评估其预测不同分化程度HCC的效能。结果 低分化组29例,中分化组37例,高分化组20例。低分化组造影剂到达时间早于中、高分化组(P均＜0.05);中、高分化组间造影剂到达时间差异无统计学意义(P＞0.05)。3组间廓清分级两两比较差异均有统计学意义(P均＜0.05)。造影剂到达时间及廓清分级均为高与低分化、中与低分化,以及中、高与低分化HCC的独立预测因素,廓清分级亦为高与中分化HCC的独立预测因素(P均＜0.05)。根据造影剂到达时间鉴别高与中分化、高与低分化、中与低分化,以及中、高与低分化HCC的AUC分别为0.615、0.787、0.690及0.724,廓清分级的AUC分别为0.801、0.927、0.795及0.841。结论 CEUS可有效预测HCC分化程度。 |
| 英文摘要: |
| Objective To explore the value of contrast-enhanced ultrasound (CEUS) for predicting differentiation degree of hepatocellular carcinoma (HCC). Methods Totally 86 HCC patients confirmed by postoperative pathology were retrospectively enrolled and divided into poorly differentiated, moderately differentiated and highly differentiated groups according to postoperative Edmondson-Steiner grading. Preoperative CEUS parameters were compared among groups, and binary logistic regression was used to analyze CEUS-related independent predictors of HCC with different differentiation. The receiver operating characteristic curves of parameters being significant different among groups were drawn, the areas under the curve (AUC) were calculated, and the efficacy for predicting HCC with different differentiation degree was evaluated. Results There were 29 cases in poorly differentiated group, 37 in moderately differentiated group and 20 cases in highly differentiated group. The arrival time of contrast agent in poorly differentiated group was earlier than that in moderately and high differentiated groups (both P＜0.05), while in moderately differentiated group was not significantly different with that in highly differentiated group (P＞0.05). The washout grade were significantly different between each 2 groups (all P＜0.05). The arrival time of contrast agent and washout grade were independent predictors of highly or poorly differentiated, moderately or poorly differentiated, moderate-highly or poorly differentiated HCC, and washout grade also was independent predictor of highly or moderately differentiated HCC (all P＜0.05). The AUC of the arrival time of contrast agent for predicting highly or moderately differentiated, highly or poorly differentiated, moderately or poorly differentiated, moderate-highly or poorly differentiated HCC was 0.615, 0.787, 0.690 and 0.724, respectively, while of washout grade was 0.801, 0.927, 0.795 and 0.841, respectively. Conclusion CEUS could be used to effectively predict differentiation degree of HCC. |
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