| 江燕辉,刘美伶,谢静雯,张建兴.极速脉搏波技术评估甲状腺功能正常桥本甲状腺炎患者颈动脉弹性改变[J].中国医学影像技术,2024,40(8):1179~1182 |
| 极速脉搏波技术评估甲状腺功能正常桥本甲状腺炎患者颈动脉弹性改变 |
| Ultrafast pulse wave velocity technique for evaluating changes of carotid artery elasticity in Hashimoto thyroiditis patients with euthyroidism |
| 投稿时间：2023-12-27 修订日期：2024-06-05 |
| DOI：10.13929/j.issn.1003-3289.2024.08.014 |
| 中文关键词: 桥本病 颈动脉 超声检查 前瞻性研究 |
| 英文关键词:Hashimoto disease carotid arteries ultrasonography prospective studies |
| 基金项目:广东省中医药局科研项目(20201137)。 |
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| 中文摘要: |
| 目的 观察极速脉搏波(UFPWV)技术评估甲状腺功能(简称甲功)正常桥本甲状腺炎(HT)患者颈动脉弹性改变的价值。方法 前瞻性对91例甲功正常的HT患者(HT组)及81名健康体检者(对照组)行常规及UFPWV颈动脉超声检查,比较组间临床资料及超声参数;以Spearman相关分析评价HT组颈动脉收缩末期脉搏波传导速度(PWV-ES)与临床指标及其他超声参数的相关性;采用多重逐步线性回归分析观察HT组颈动脉PWV-ES升高的独立影响因素。结果 组间甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)、总胆固醇(TC)、低密度脂蛋白及中性粒细胞-淋巴细胞比率(NLR)差异均有统计学意义(P均＜0.05)。HT组颈动脉PWV-ES显著高于对照组(P＜0.05);组间颈动脉内-中膜厚度(CIMT)及颈动脉收缩期起始脉搏波传导速度(PWV-BS)差异均无统计学意义(P均＞0.05)。HT组颈动脉PWV-ES与患者年龄、体质量指数、TPOAb、TC、甘油三酯、NLR及CIMT均呈正相关(r=0.217~0.707,P均＜0.05)。患者年龄、TPOAb及NLR均为甲功正常HT患者颈动脉PWV-ES升高的独立影响因素(P均＜0.05)。结论 UFPWV技术可用于评价甲功正常HT患者颈动脉弹性改变,其中PWV-ES是较为敏感的指标。 |
| 英文摘要: |
| Objective To explore the value of ultrafast pulse wave velocity (UFPWV) technique for evaluating changes of carotid artery elasticity in Hashimoto thyroiditis (HT) patients with euthyroidism. Methods Conventional ultrasound and UFPWV for carotid artery were prospectively performed in 91 HT patients with euthyroidism (HT group) and 81 healthy subjects (control group). Clinical data and ultrasonic parameters were compared between groups. Spearman correlation analysis was performed to observe the correlations of carotid pulse wave velocity in end of systole (PWV-ES) with clinical indexes and other ultrasonic parameters in HT group. Multiple stepwise linear regression analysis was used to screen the independent impact factors of increased carotid PWV-ES in HT group. Results Significant differences of thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), total cholesterol (TC), low density lipoprotein and neutrophil-lymphocyte ratio (NLR) were found between groups (all P＜0.05). The carotid PWV-ES in HT group was significantly higher than that in control group (P＜0.05), while no significant difference of carotid artery intima-media thickness (CIMT) nor carotid pulse wave velocity in beginning of systole (PWV-BS) was found between groups (both P＞0.05). Carotid PWV-ES in HT group was positively correlated with patients' age, body mass index, TPOAb, TC, triglyceride, NLR and CIMT (r=0.217—0.707, all P＜0.05). Patients' age, TPOAb and NLR were all independent impact factors of increased carotid PWV-ES in HT patients with euthyroidism (all P＜0.05). Conclusion UFPWV technique could be used to evaluate changes of carotid artery elasticity in HT patients with euthyroidism, among which PWV-ES was relatively sensitive. |
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