| 邹全,陈飞,孟文玉,郑红.帕金森病患者经颅黑质超声特征与MRI黑质铁沉积表现的相关性[J].中国医学影像技术,2024,40(8):1160~1163 |
| 帕金森病患者经颅黑质超声特征与MRI黑质铁沉积表现的相关性 |
| Correlations of transcranial sonography of substantia nigra characteristics with MRI iron deposition on substantia nigra in patients with Parkinson disease |
| 投稿时间：2024-03-08 修订日期：2024-05-06 |
| DOI：10.13929/j.issn.1003-3289.2024.08.009 |
| 中文关键词: 帕金森病 黑质 铁 超声检查 磁共振成像 |
| 英文关键词:Parkinson disease substantia nigra iron ultrasonography magnetic resonance imaging |
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| 中文摘要: |
| 目的 观察帕金森病(PD)经颅黑质超声(SN-TCS)特征与MRI黑质铁沉积的相关性。方法 回顾性分析120例PD患者SN-TCS及颅脑MRI,根据黑质定量磁化率成像(QSM)测值将患者归入铁沉积阳性组(n=46,阳性组)及铁沉积阴性组(n=74,阴性组);比较2组SN-TCS及MRI参数并行相关性分析。结果 阳性组黑质超声高回声阳性占比、强回声面积、QSM值,以及黑质强回声面积与中脑面积比值(S/M)均高于阴性组(P均＜0.001);组间中脑面积差异无统计学意义(P＞0.05)。SN-TCS所见黑质强回声面积及S/M均与MRI黑质QSM值呈低-中度正相关(r=0.497、0.529,P均＜0.001)。结论 PD患者SN-TCS特征与MRI黑质铁沉积存在相关性;其中,黑质强回声面积及S/M对评估黑质铁沉积具有一定价值。 |
| 英文摘要: |
| Objective To explore the correlations of transcranial sonography of substantia nigra (SN-TCS) characteristics with MRI iron deposition on substantia nigra in patients with Parkinson disease (PD). Methods Data of SN-TCS and craniocerebral MRI in 120 PD patients were retrospectively analyzed. The patients were divided into iron deposition positive group (positive group, n=46) and iron deposition negative group (negative group, n=74) according to quantitative susceptibility mapping (QSM) value. Then parameters of SN-TCS and MRI were compared between groups (both P＜0.05), and correlation analysis were also performed. Results The proportion of high echo positive, strong echo area and QSM value of substantia nigra, as well as of hyper-substantia nigra area/midbrain area (S/M) in positive group were all higher than those in negative group (all P＜0.001). No significant difference of midbrain area was found between groups (P＞0.05). Strong echo area of substantia nigra and S/M based on SN-TCS were both low-medium positively correlated with substantia nigra QSM value showed on MRI (r=0.497, 0.529, both P＜0.001). Conclusion SN-TCS characteristics of PD patients were correlated with MRI iron deposition on substantia nigra, among which strong echo area and S/M were valuable for evaluating iron deposition on substantia nigra. |
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