| 乔雅倩,王玉龙,白培瑞,王成健,任延德,毕玉珍.终末期肾病患者脑网络动态功能连接[J].中国医学影像技术,2024,40(7):997~1002 |
| 终末期肾病患者脑网络动态功能连接 |
| Dynamic functional connectivity of brain networks in end-stage renal disease patients |
| 投稿时间：2023-10-25 修订日期：2024-01-15 |
| DOI：10.13929/j.issn.1003-3289.2024.07.009 |
| 中文关键词: 肾衰竭,慢性 磁共振成像 功能连接 |
| 英文关键词:kidney failure, chronic magnetic resonance imaging functional connectivity |
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| 中文摘要: |
| 目的 观察终末期肾病(ESRD)患者脑网络动态功能连接改变。方法 回顾性分析30例ESRD患者(ESRD组)与33名健康受试者(对照组),采用图论分析方法基于颅脑静息态功能MRI(rs-fMRI)对动态功能连接(dFC)参数进行组间比较,评估ESRD患者dFC与网络拓扑结构异常,并以Pearson相关性分析观察其与临床变量的相关性。结果 相比对照组,ESRD组时间分数与平均驻留时间在状态二下升高、状态三下减低(P均＜0.05),其异常功能连接主要见于默认模式网络、感觉运动网络、皮质下核、执行和注意网络、视觉网络、小脑网络内及网络间。ESRD组网络密度及双侧颞上回节点度均低于对照组(P均＜0.05)。ESRD组状态二、三下的功能连接及图论属性异常参数与其临床指标均无明显相关(P均＞0.05)。结论 ESRD患者存在与认知功能损伤有关的脑动态网络时间属性及网络拓扑结构异常。 |
| 英文摘要: |
| Objective To investigate the temporal properties of dynamic functional connectivity of brain networks and the variability of network topology in patients with end-stage renal disease (ESRD). Methods Data of 30 ESRD patients (ESRD group) and 33 healthy subjects (control group) were retrospectively analyzed. Based on cranial resting-state functional MRI (rs-fMRI), dynamic functional connectivity (dFC) and graph theory analysis were employed, and the abnormalities in network topology and dFC in ESRD patients were assessed through comparison of groups. Pearson correlation analysis was used to observe the correlation between abnormal dFC indicators and clinical variables. Results Compared with control group, temporal scores and the mean residence time in ESRD group were significantly higher under state Ⅱ but significantly lower under state Ⅲ (both P＜0.05). The abnormal functional connectivity in ESRD patients under states Ⅱ and Ⅲ distributed mainly within and between default mode network, sensorimotor network, subcortical nuclei, execution and attention network, visual network and cerebellum networks. Network density and bilateral superior temporal gyrus nodal degrees in ESRD group were all significantly lower than those in control group (all P＜0.05). No significant correlation was found between the abnormal parameters of functional connectivity and graph theory attributes in ESRD group and clinical indicators under states Ⅱ nor Ⅲ (all P＞0.05). Conclusion ESRD patients had abnormal temporal attributes and network topology of brain dynamic networks related to cognitive impairments. |
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