| 郑璐,胡玉敬,张新超,李康,蔡晓雨,刘家乐,边艳珠.原发系统性间变性大细胞淋巴瘤18F-FDG PET/CT表现[J].中国医学影像技术,2023,39(12):1798~1802 |
| 原发系统性间变性大细胞淋巴瘤18F-FDG PET/CT表现 |
| 18F-FDG PET/CT manifestations of primary systemic anaplastic large cell lymphoma |
| 投稿时间：2023-06-27 修订日期：2023-11-06 |
| DOI：10.13929/j.issn.1003-3289.2023.12.013 |
| 中文关键词: 淋巴瘤 正电子发射断层显像 体层摄影术,X线计算机 氟脱氧葡萄糖F18 |
| 英文关键词:lymphoma positron-emission tomography tomography, X-ray computer fluorodeoxyglucose F18 |
| 基金项目:国家自然科学基金（82302252）、河北省自然科学基金（H2022307068）。 |
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| 中文摘要: |
| 目的 观察原发系统性间变性大细胞淋巴瘤（ALCL）18F-FDG PET/CT表现。方法 纳入21例原发系统性ALCL，观察病灶PET/CT表现。结果 21例中，15例ALK+、6例ALK-ALCL；19例累及多部位淋巴结，主要包括颈部（13例）、纵隔（12例）及腹膜后（12例）淋巴结，2例仅累及单一部位淋巴结。12例累及结外器官/部位，其中6例累及软组织如皮肤、肌肉等，4例累及骨骼，14例累及脏器，包括肺部（4例）、肝脏（3例）、胰腺（2例）、肾脏（2例）、胃肠道（2例）及甲状腺（1例）。21例中，19例淋巴结形态欠规则并融合成团，17例密度均匀，3例可见坏死，1例可见钙化。21例病灶均表现为高代谢，受累淋巴结最大标准摄取值（SUVmax）、平均标准摄取值（SUVmean）分别为17.04±9.94、9.96±6.15，全部病灶肿瘤代谢体积（MTV）、病灶糖酵解总量（TLG）分别为92.54（67.61，249.21） cm3、723.46（419.78，1461.17） g。受累淋巴结最大径与其SUVmax、SUVmean与无明显相关（P均>0.05），与全部病灶MTV、TLG呈正相关（r=0.696、0.767，P均<0.001）。Ann Arbor分期与受累淋巴结最大径、SUVmax和SUVmean，以及全部病灶MTV和TLG呈正相关（r=0.467、0.458、0.702、0.780、0.664，P均<0.05）。结论 原发系统性ALCL的18F-FDG PET/CT表现具有一定特征，其代谢参数SUVmax、SUVmean、MTV及TLG变化明显。 |
| 英文摘要: |
| Objective To observe the 18F-FDG PET/CT manifestations of primary systemic anaplastic large cell lymphoma (ALCL). Methods A total of 21 patients with primary systemic ALCL were enrolled, and PET/CT manifestations were observed.Results Among 21 cases of ALCL, there were 15 cases of ALK+ and 6 cases of ALK-. Affected lymph nodes in multiple site were observed in 19 cases, mainly located in the neck (n=13), mediastinum (n=12 cases) or retroperitoneum (n=12), while single site affected lymph node was notice in 2 cases. Extranodal organs/site involvements were found in 12 cases, including 6 cases of soft tissue (such as skin, muscles, etc.), 4 cases of bone, 14 cases of organs, including 4 cases of lung, 3 cases of liver, 2 cases of pancreas, 2 cases of kidney, 2 cases of gastrointestinal tract and 1 case of thyroid. Among 21 cases of ALCL, 19 with irregular lymph node morphology and fused into clusters, 17 with uniform density, 3 with necrosis and 1 with calcification. All ALCL lesions in 21 cases showed hypermetabolism, the maximum standard uptake value (SUVmax) and the mean standard uptake value (SUVmean) of the affected lymph node was 17.04±9.94 and 9.96±6.15, respectively, while the metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of all lesions was 92.54 (67.61, 249.21) cm3 and 723.46 (419.78, 1 461.17) g, respectively. The maximum diameter of the affected lymph node was not significantly correlated with SUVmax nor SUVmean (both P>0.05), but positively correlated with MTV and TLG of all lesions (r=0.696, 0.767, both P<0.001). Ann Arbor staging was positively correlated with the maximum diameter, SUVmax and SUVmean of the affected lymph node, also MTV and TLG of all lesions (r=0.467, 0.458, 0.702, 0.780, 0.664, all P<0.05). Conclusion 18F-FDG PET/CT manifestations of primary systemic ALCL were characteristic, with significant changed metabolic parameters, including SUVmax, SUVmean, MTV and TLG. |
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