欢迎访问《中国医学影像技术》网站。

2025-06-14 星期六
首页 | 本刊简介 | 编委会 | 收录情况 | 投稿须知 | 期刊订阅 | 科学家精神 | 科学数据银行 | 广告招商

张彦梅,许莎莎,晁芳芳,于艳霞,王兵元,王旭,韩星敏.对比¹⁸F-NOTA-FAPI-04与¹⁸F-FDG PET/CT显像诊断腹膜转移癌[J].中国医学影像技术,2023,39(8):1215~1220

对比¹⁸F-NOTA-FAPI-04与¹⁸F-FDG PET/CT显像诊断腹膜转移癌

Comparison on ¹⁸F-NOTA-FAPI-04 and ¹⁸F-FDG PET/CT imaging for diagnosing peritoneal carcinomatosis

投稿时间：2023-04-18 修订日期：2023-06-07

DOI：10.13929/j.issn.1003-3289.2023.08.021

中文关键词: 腹膜肿瘤肿瘤转移体层摄影术,X线计算机正电子发射断层显像成纤维细胞前瞻性研究

英文关键词:peritoneal neoplasms neoplasm metastasis tomography, X-ray computed positron-emission tomography fibroblasts prospecti studies

基金项目:国家自然科学基金项目(82171983)。

作者	单位	E-mail
张彦梅	郑州大学第一附属医院核医学科, 河南郑州 450000
许莎莎	郑州大学第一附属医院核医学科, 河南郑州 450000
晁芳芳	郑州大学第一附属医院核医学科, 河南郑州 450000
于艳霞	郑州大学第一附属医院核医学科, 河南郑州 450000
王兵元	郑州大学第一附属医院核医学科, 河南郑州 450000
王旭	郑州大学第一附属医院核医学科, 河南郑州 450000
韩星敏	郑州大学第一附属医院核医学科, 河南郑州 450000	xmhan@zzu.edu.cn

摘要点击次数: 1832

全文下载次数: 661

中文摘要:

目的对比¹⁸F-成纤维细胞激活蛋白抑制剂(FAPI)-04与¹⁸F-FDG PET/CT诊断腹膜转移癌(PC)的价值。方法前瞻性纳入42例疑诊PC患者行全身¹⁸F-1,4,7-三氮杂环壬烷-N,N',N″-三乙酸(NOTA)-FAPI-04和¹⁸F-FDG PET/CT检查,以病理学结果为金标准,比较2种显像的PC指数(PCI)、病灶最大标准摄取值(SUV_max)及靶-背景比(TBR)差异;绘制受试者工作特征曲线,评估2种显像诊断PC效能。结果 42例中,病理确诊31例PC。¹⁸F-NOTA-FAPI-04诊断PC的敏感度、特异度和准确率分别为93.55%、72.73%和88.10%,¹⁸F-FDG PET/CT分别为74.19%、54.55%和69.05%,前者的敏感度及准确率均高于后者(P均＜0.05);以前者所获PCI、所测PC的SUV_max、TBR均高于后者(P均＜0.001)。分别以2.31及2.52 为FAPI-SUV_max、FDG-SUV_max的截断值,¹⁸F-NOTA-FAPI-04及¹⁸F-FDG PET/CT诊断PC的曲线下面积(AUC)分别为0.839及0.630,差异有统计学意义(P=0.002);分别以1.60及0.73为FAPI-TBR、FDG-TBR的截断值,¹⁸F-NOTA-FAPI-04及¹⁸F-FDG PET/CT诊断PC的AUC分别为0.856及0.604,差异亦有统计学意义(P=0.005)。结论 ¹⁸F-NOTA-FAPI-04 PET/CT诊断PC较¹⁸F-FDG PET/CT更具优势。

英文摘要:

Objective To compare the value of ¹⁸F-fibroblast activation protein inhibitor (FAPI)-04 and ¹⁸F-FDG PET/CT for diagnosing peritoneal carcinomatosis (PC). Methods Totally 42 patients with suspected PC who underwent whole body ¹⁸F-1,4,7-triazacyclononane-N,N',N″-triacetic acid (NOTA)-FAPI-04 and ¹⁸F-FDG PET/CT imaging sequentially were prospectively enrolled. Taken histopathological results as the gold standards, PC index (PCI), the maximum standard uptake value (SUV_max) and target-to-back ground ratio (TBR) were compared between 2 kinds of images. The receiver operating characteristic curves were drawn, and the efficacy of 2 kinds of images for diagnosing PC were evaluated. Results Pathological results proved 31 cases with PC. The sensitivity, specificity and accuracy of ¹⁸F-NOTA-FAPI-04 for diagnosing PC was 93.55%, 72.73% and 88.10%, respectively, of ¹⁸F-FDG PET/CT was 74.19%, 54.55% and 69.05%, respectively. The sensitivity and accuracy of the former for diagnosing PC were higher than those of the latter (both P＜0.05), and PCI of 31 patients with PC calculated with the former was higher than that of the latter (P＜0.001), SUV_max and TBR of PC measured with the former were higher than those with the latter (both P＜0.001).Taken 2.31 and 2.52 as the cut-off value of FAPI-SUV_max and FDG-SUV_max, respectively, the area under the curve (AUC) of ¹⁸F-NOTA-FAPI-04 and ¹⁸F-FDG PET/CT for diagnosing PC was 0.839 and 0.630, respectively, which was significantly different (P=0.002). Taken 1.60 and 0.73 as the cut-off value of FAPI-TBR and FDG-TBR, respectively, the AUC of ¹⁸F-NOTA-FAPI-04 and ¹⁸F-FDG PET/CT for diagnosing PC was 0.856 and 0.604, respectively, also being significantly different (P=0.005). Conclusion Compared with ¹⁸F-FDG PET/CT, ¹⁸F-NOTA-FAPI-04 PET/CT was better for diagnosing PC.

查看全文查看/发表评论下载PDF阅读器