| 杨昆,袁新春,胡佳,张哲元,夏侯宇,杨昭.血流向量成像技术评估以蒽环类药物行化学治疗后弥漫性大B细胞淋巴瘤患者左心室舒张功能[J].中国医学影像技术,2023,39(8):1181~1185 |
| 血流向量成像技术评估以蒽环类药物行化学治疗后弥漫性大B细胞淋巴瘤患者左心室舒张功能 |
| Vector flow mapping for evaluating left ventricular diastolic function in patients with diffuse large B cell lymphoma after anthracycline chemotherapy |
| 投稿时间：2023-04-10 修订日期：2023-06-16 |
| DOI：10.13929/j.issn.1003-3289.2023.08.013 |
| 中文关键词: 淋巴瘤,B细胞 心室功能,左 蒽环素 血流向量成像技术 |
| 英文关键词:lymphoma, B-cell ventricular function, left anthracyclines vector flow mapping |
| 基金项目:江西省教育厅科学技术研究项目(GJJ2200206)。 |
|
| 摘要点击次数: 1924 |
| 全文下载次数: 532 |
| 中文摘要: |
| 目的 观察血流向量成像(VFM)技术评估蒽环类药物化学治疗(化疗)后弥漫性大B细胞淋巴瘤(DLBCL)患者左心室舒张功能改变的价值。方法 前瞻性纳入36例拟接受蒽环类药物化疗的DLBCL患者(化疗组)和46名健康人(对照组)。分别于化疗组化疗前(T0)对2组,于化疗2个周期(T2)及化疗4个周期后(T4)对化疗组行常规超声心动图检查,获取包括左心房容积指数(LAVI)、E、e'、E/A、e'/a'及E/e'在内的常规心功能参数;以VFM获取等容舒张期(IR)、快速充盈期(RF)、缓慢充盈期(SF)及心房收缩期(AC)平均能量损耗(aEL)和左心室内压差(IVPD);比较组间及化疗组不同时间点上述参数差异,以相关性分析观察VFM技术评估化疗后左心室舒张功能改变的价值。结果 化疗组各时间点LAVI、e'、e'/a'、aEL-RF、aEL-AC、IVPD-IR、IVPD-RF、IVPD-SF及IVPD-AC差异均有统计学意义(P均＜0.05);T0与T2 的aEL-AC、IVPD-IR及IVPD-AC差异,T0与T4的LAVI、e'、e'/a'、E/e'、aEL-RF、aEL-AC、IVPD-IR、IVPD-RF、IVPD-SF及IVPD-AC差异,T2与T4的LAVI、e'、E/e'、aEL-RF、aEL-AC、IVPD-IR、IVPD-RF、IVPD-SF及IVPD-AC差异均有统计学意义(P均＜0.05)。化疗组E与aEL-AC、IVPD-IR、IVPD-RF及IVPD-AC均呈正相关(r均＞0.2,P均＜0.001),E/A与IVPD-IR呈负相关(r=-0.208,P＜0.001)、与IVPD-RF呈正相关(r=0.244,P＜0.001),E/e'、LAVI均与aEL-AC、IVPD-IR及IVPD-AC呈正相关(r均＞0.4,P均＜0.001),e'、e'/a'均与aEL-AC、IVPD-IR及IVPD-AC呈负相关(r均＜-0.2,P均＜0.001)。结论 利用VFM技术可有效评估蒽环类药物化疗后DLBCL患者左心室舒张功能改变。 |
| 英文摘要: |
| Objective To observe the value of vector flow mapping (VFM) for evaluating left ventricular diastolic function in patients with diffuse large B cell lymphoma (DLBCL) after anthracycline chemotherapy. Methods Thirty-six DLBCL patients who would receive anthracycline chemotherapy (chemotherapy group) and 46 healthy people (control group) were prospectively enrolled. Routine echocardiography was performed in both groups before chemotherapy (T0) and in chemotherapy group after 2 cycles (T2) and 4 cycles chemotherapy (T4). Routine cardiac function parameters, including left atrial volume index (LAVI), E, e', E/A, e'/a' and E/e were obtained. VFM examination was performed in chemotherapy group to acquire average energy loss (aEL) and intraventricular pressure difference (IVPD) of isovolumetric relaxation (IR), rapid filling (RF), slow filling (SF) and atrial contraction (AC) period. The above parameters were compared between groups chemotherapy and among different time points in chemotherapy group. Then correlation analysis was performed, and the value of VFM for evaluating left ventricular diastolic function changes after chemotherapy of DLBCL was observed. Results Significant differences of LAVI, e', e'/a', aEL-RF, aEL-AC, IVPD-IR, IVPD-RF, IVPD-SF and IVPD-AC were found among different points in chemotherapy group (all P＜0.05). There were significant differences of aEL-AC, IVPD-IR and IVPD-AC between T0 and T2,of LAVI, e', e'/a', E/e', aEL-RF, aEL-AC, IVPD-IR, IVPD-RF, IVPD-SF and IVPD-AC between T0 and T4, of LAVI, e', E/e', aEL-RF, aEL-AC, IVPD-IR, IVPD-RF, IVPD-SF and IVPD-AC between T2 and T4 (all P＜0.05). In chemotherapy group, E was positively correlated with aEL-AC, IVPD-IR, IVPD-RF and IVPD-AC (all r＞0.2, all P＜0.001), E/A was negatively correlated with IVPD-IR (r=-0.208, P＜0.001) but positively correlated with IVPD-RF (r=0.244, P＜0.001), E/e' and LAVI were positively correlated with aEL-AC, IVPD-IR and IVPD-AC (all r＞0.4, all P＜0.001), while e' and e'/a' were negatively correlated with aEL-AC, IVPD-IR and IVPD-AC (all r＜-0.2, all P＜0.001). Conclusion VFM could be used to effectively evaluate left ventricular diastolic function in patients with DLBCL after anthracycline chemotherapy. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
