| 王焱钧,王敏,胡建宇,葛洪,刘德林,李玲,王远成,居胜红.基于黄金角径向稀疏并行采集技术动态对比增强MRI鉴别诊断甲状腺良、恶性结节[J].中国医学影像技术,2023,39(8):1176~1180 |
| 基于黄金角径向稀疏并行采集技术动态对比增强MRI鉴别诊断甲状腺良、恶性结节 |
| Dynamic contrast-enhanced MRI with golden-angle radial sparse parallel scanning technology for differential diagnosis of benign and malignant thyroid nodules |
| 投稿时间：2023-04-10 修订日期：2023-06-04 |
| DOI：10.13929/j.issn.1003-3289.2023.08.012 |
| 中文关键词: 甲状腺肿瘤 磁共振成像 |
| 英文关键词:thyroid neoplasms magnetic resonance imaging |
| 基金项目:国家重点研发计划重点专项(2021YFF0501504)。 |
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| 中文摘要: |
| 目的 探讨基于黄金角径向稀疏并行容积内插检查(GRASP-VIBE)技术动态对比增强(DCE)MRI鉴别诊断甲状腺良、恶性结节的价值。方法 纳入41枚甲状腺结节,根据病理结果将其分为恶性组(n=15)及良性组(n=26)。采用GRASP-VIBE技术获取结节DCE-MRI定量及半定量参数,比较各参数鉴别甲状腺良、恶性结节的效能;以二元logistic回归分析筛选鉴别诊断甲状腺良、恶性结节的独立因子。结果 恶性组达峰时间(TTP)长于(P＜0.05),而容积转运常数(Ktrans)、反流速率常数(Kep)、60 s内曲线下初始面积(iAUC定量)均小于良性组(P均＜0.05)。Kep是鉴别诊断甲状腺良、恶性结节的独立因子(OR=0.028,P=0.002),以1.10/min为截断值,其鉴别甲状腺良、恶性结节的曲线下面积为0.88,优于iAUC定量及TTP(P均＜0.05),与Ktrans比较差异无统计学意义(P＞0.05)。结论 基于GRASP-VIBE的DCE-MRI灌注参数可用于鉴别诊断甲状腺良、恶性结节,以Kep诊断效能最佳。 |
| 英文摘要: |
| Objective To observe the value of dynamic contrast-enhanced (DCE) MRI perfusion parameters with golden-angle radial sparse parallel-volumetric interpolated breath-hold examination (GRASP-VIBE) for differential diagnosis of benign and malignant thyroid nodules. Methods A total of 41 thyroid nodules were enrolled and divided into malignant (n=15) and benign group (n=26) according to pathologic results. GRASP-VIBE was used to obtain quantitative and semi-quantitative DCE-MRI parameters, and the efficacy of each parameter for differentiating benign and malignant thyroid nodules was analyzed. The binary logistic regression analysis was used to screen independent factors for differentiating benign and malignant thyroid nodules. Results The time to peak (TTP) of malignant group was longer than that of benign group (P＜0.05), but volume transfer constant (Ktrans), reflux rate constant (Kep) and quantitative initial area under the curve within 60 sec (iAUCquantification) of malignant group were all smaller than those of benign group (all P＜0.05). Kep was an independent factor for differential diagnosis of benign and malignant thyroid nodules (OR=0.028, P=0.002). Taken 1.10/min as the cut-off value, the area under the curve of Kep for differentiating benign and malignant thyroid parameters was 0.88, superior to that of iAUCquantification and TTP (both P＜0.05) but not significant different with that of Ktrans (P＞0.05). Conclusion DCE-MRI perfusion parameters based on GRASP-VIBE could be used to differentiate benign and malignant thyroid nodules, among which Kep had the best diagnostic efficacy. |
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