| 孙永兵,戚昕,苏路路,邹智,屈敏,闫峰山,朱嘉栋,仓顺东,程晓光,李永丽.化学治疗Ⅲ期肺鳞状细胞癌及肺腺癌后患者骨密度变化[J].中国医学影像技术,2023,39(7):1019~1023 |
| 化学治疗Ⅲ期肺鳞状细胞癌及肺腺癌后患者骨密度变化 |
| Changes of bone mineral density in stag Ⅲ lung squamous cell carcinoma and lung adenocarcinoma patients after chemotherapy |
| 投稿时间：2023-02-27 修订日期：2023-05-13 |
| DOI：10.13929/j.issn.1003-3289.2023.07.015 |
| 中文关键词: 肺肿瘤 癌,鳞状细胞 腺癌 骨密度 药物治疗 体层摄影术,X线计算机 |
| 英文关键词:lung neoplasms carcinoma, squamous cell adenocarcinoma bone density drug therapy tomography, X-ray computed |
| 基金项目: |
| 作者 | 单位 | E-mail | | 孙永兵 | 郑州大学附属人民医院医学影像科, 河南 郑州 450003 | | | 戚昕 | 河南省人民医院医学影像科 河南省慢病健康管理重点实验室, 河南 郑州 450003 | | | 苏路路 | 河南省人民医院肿瘤中心 河南省慢病健康管理重点实验室, 河南 郑州 450003 | | | 邹智 | 河南省人民医院医学影像科 河南省慢病健康管理重点实验室, 河南 郑州 450003 | | | 屈敏 | 河南省人民医院健康管理学科 河南省慢病健康管理重点实验室, 河南 郑州 450003 | | | 闫峰山 | 河南省人民医院医学影像科 河南省慢病健康管理重点实验室, 河南 郑州 450003 | | | 朱嘉栋 | 河南省人民医院健康管理学科 河南省慢病健康管理重点实验室, 河南 郑州 450003 | | | 仓顺东 | 河南省人民医院肿瘤中心 河南省慢病健康管理重点实验室, 河南 郑州 450003 | | | 程晓光 | 北京积水潭医院放射科, 北京 102208 | | | 李永丽 | 河南省人民医院健康管理学科 河南省慢病健康管理重点实验室, 河南 郑州 450003 | shyliyongli@126.com |
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| 中文摘要: |
| 目的 观察化学治疗(化疗)Ⅲ期肺鳞状细胞癌(鳞癌)及肺腺癌后患者骨密度(BMD)变化。方法 回顾性分析经病理确诊并接受规律化疗的44例Ⅲ期肺鳞癌(鳞癌组)和47例Ⅲ期肺腺癌(腺癌组),以定量CT(QCT)测量其化疗前日(基线期)及第1、2、3个周期后1周内L1~L2 BMD;比较组间基线资料,观察不同时间点组间及组内BMD差异。结果 组间基线资料差异均无统计学意义(P均>0.05)。鳞癌组第3个化疗周期后BMD较腺癌组降低(t=-2.572,P=0.011),其余时间点组间BMD差异均无统计学意义(P均>0.05)。相比基线期,鳞癌组第2、3个化疗周期后BMD均显著降低(P均<0.01),其余不同时间点BMD差异均无统计学意义(P均>0.05);腺癌组化疗前、后BMD差异无统计学意义(F=0.331,P=0.803)。结论 3个周期化疗后Ⅲ期肺鳞癌患者BMD降低,而腺癌患者BMD未见明显变化。 |
| 英文摘要: |
| Objective To explore changes of bone mineral density (BMD) in patients with stage Ⅲ lung squamous cell carcinoma and adenocarcinoma after chemotherapy. Methods Data of 44 patients with stage Ⅲ lung squamous cell carcinoma (squamous cell carcinoma group) and 47 with stage Ⅲ lung adenocarcinoma (adenocarcinoma group) who underwent regular chemotherapy after pathological diagnosis were retrospectively analyzed. BMD of L1-L2 at baseline (before chemotherapy) and after the first, second, and third cycle of chemotherapy were measured using quantitative CT (QCT). Baseline data were compared between groups, while BMD at different time points were compared between groups and within groups. Results No significant difference of baseline data was found between groups (all P>0.05). After the third cycle of chemotherapy, BMD in squamous cell carcinoma group was lower than that in adenocarcinoma group (t=-2.572, P=0.011), while no significant difference of BMD was detected between groups at the other time points (all P>0.05). Compared with that in baseline, after the second and the third cycle of chemotherapy, BMD significantly decreased (both P<0.01), while no significant significance of BMD was in squamous cell carcinoma group observed among other time points (all P>0.05). There was no significant difference of BMD before and after chemotherapy in adenocarcinoma group (F=0.331, P=0.803). Conclusion After 3 cycles of chemotherapy, BMD decreased in patients with stage Ⅲ lung squamous cell carcinoma, while in those with adenocarcinoma did not change obviously. |
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