| 李灿,张晓军,刘家金,张锦明,王瑞民,富丽萍.PET新型Tau蛋白分子探针18F-S16用于阿尔茨海默病患者[J].中国医学影像技术,2023,39(7):972~977 |
| PET新型Tau蛋白分子探针18F-S16用于阿尔茨海默病患者 |
| PET novel Tau protein molecular probe 18F-S16 aplicated in patients with Alzheimer's disease |
| 投稿时间：2023-03-16 修订日期：2023-04-24 |
| DOI：10.13929/j.issn.1003-3289.2023.07.003 |
| 中文关键词: 阿尔茨海默病 正电子发射断层显像 分子探针 |
| 英文关键词:Alzheimer disease positron-emission tomography molecular probes |
| 基金项目:北京自然科学基金(7192192)。 |
|
| 摘要点击次数: 1621 |
| 全文下载次数: 502 |
| 中文摘要: |
| 目的 观察PET新型Tau蛋白分子探针18F-S16用于阿尔茨海默病(AD)的价值。方法 前瞻性纳入6例AD患者、2例非AD痴呆患者,以及6名老年和2名年轻健康志愿者,行头部18F-S16 PET/MR扫描;计算注射药物后40~60 min及70~90 min皮质/小脑标准摄取值比值(SUVR),并观察其与Logan图解分析所得分布体积比(DVR)的相关性,基于ROI和体素分析比较摄取差异。结果 AD患者皮质放射性摄取明显增加,而老年及年轻健康志愿者未见皮质显著放射性浓聚;三者均可见基底节区非特异性摄取。18F-S16注射后90 min内,AD患者SUVR进行性增加,并随时间延长而与老年和年轻健康志愿者差距增大。与老年健康志愿者相比,AD患者双侧枕叶皮质、舌回及后扣带回皮质/楔前叶18F-S16放射性滞留明显增加。注射药物后40~60 min及70~90 min,5名老年健康志愿者枕叶SUVR与DVR的相关系数R2分别为0.826 2和0.909 1,其在内侧颞叶皮质为0.989 7和0.983 6,在额叶为0.749 6和0.752 6,顶叶为0.930 6和0.921 7,外侧颞叶为0.934 2和0.936 3,在后扣带回为0.749 6和0.752 6。结论 作为PET Tau蛋白分子探针,18F-S16在AD患者脑内皮质区存在显著放射性滞留,具有一定临床应用潜力。 |
| 英文摘要: |
| Objective To observe the application value of PET novel Tau protein molecular probe 18F-S16 in patients with Alzheimer's disease (AD). Methods Six AD patients, 2 non AD dementia patients, 6 elderly and 2 young healthy volunteers were prospectively enrolled. 18F-S16 PET/MRI of the head was performed, and cortical/cerebellar standard uptake value ratio (SUVR) 40-60 min and 70-90 min after injection were calculated, the correlation of SUVR with distribution volume ratio (DVR) obtained from Logan graphical analysis was analyzed. The uptakes were compared based on ROI and voxel analysis among different populations. Results Increased cortical radiation uptake was observe in AD patients, but not in elderly nor young healthy volunteers. Non-specific uptake in the basal ganglia region was detected in AD patients as well as in elderly and young healthy volunteers. Within 90 min after injection of 18F-S16, SUVR of AD patients gradually increased, and the gap of SUVR between AD patients and elderly and young healthy volunteers increased with time going. Compared with elderly healthy volunteers, 18F-S16 radioactive retention increased in bilateral occipital cortex, lingual gyrus, and posterior cingulate cortex/anterior cuneiform cortex in AD patients. The correlation coefficients R2 between occipital SUVR and DVR of 5 elderly healthy volunteers was 0.826 2 and 0.909 1 40-60 min and 70-90 min after injection, respectively, which was 0.778 5 and 0.865 2 in the medial temporal cortex, 0.749 6 and 0.752 6 in the frontal lobe, 0.930 6 and 0.921 7 in the parietal lobe, 0.934 2 and 0.936 3 in the lateral temporal lobe, 0.989 7 and 0.983 6 in the posterior cingulate gyrus, respectively. Conclusion As a PET Tau protein molecular probe, 18F-S16 presented as significant radioactive retention in cerebral cortex of AD patients, hence having certain potential for application in clinical practice. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
