| 祝安惠,张卫方.Xp11.2易位/TFE3基因融合相关性肾细胞癌18F-FDG PET/CT特征[J].中国医学影像技术,2023,39(6):885~889 |
| Xp11.2易位/TFE3基因融合相关性肾细胞癌18F-FDG PET/CT特征 |
| 18F-FDG PET/CT characteristics of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion |
| 投稿时间：2023-03-01 修订日期：2023-04-11 |
| DOI：10.13929/j.issn.1003-3289.2023.06.020 |
| 中文关键词: 肾肿瘤 Xp11.2易位/TFE3基因融合 体层摄影术,X线计算机 正电子发射断层显像 |
| 英文关键词:kidney neoplasms Xp11.2 translocation/TFE3 gene fusions tomography, X-ray computed positron-emission tomography |
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| 中文摘要: |
| 目的 观察Xp11.2易位/TFE3基因融合相关性肾细胞癌（Xp11.2易位肾细胞癌） PET/CT表现。方法 回顾性分析6例Xp11.2易位肾细胞癌患者，观察其PET/CT表现。结果 6例肿瘤最大径6.5~15.5 cm、中位最大径10.30 cm；5例呈高、低混杂密度肿块，1例呈均匀低密度；5例为囊实性、1例为实性肿块；5例18F-FDG摄取增高，最大标准摄取值（SUVmax）为2.5~6.5、中位数为6.2，1例18F-FDG摄取低于相邻肾实质；5例肿瘤内或边缘可见散在点状/条状/结节状钙化灶；3例合并肾静脉/下腔静脉瘤栓，表现为静脉管腔增粗，放射性摄取增高；2例合并远处转移，分别为肺转移及肝、肺、骨多器官转移，均表现为不同程度放射性摄取增高。结论 Xp11.2易位肾细胞癌PET/CT表现具有一定特征性，多呈较大软组织肿块伴囊变及钙化，18F-FDG摄取多增高。 |
| 英文摘要: |
| Objective To observe the PET/CT manifestations of renal cell carcinoma (RCC) associated with Xp11.2 translocation/TFE3 gene fusion (Xp11.2 translocation RCC). Methods Data of 6 patients with Xp11.2 translocation RCC were retrospectively analyzed, and the PET/CT manifestations of tumors were observed. Results The maximum diameter of 6 tumors was 6.5-15.5 cm, with the median maximum diameter of 10.30 cm. Among 6 cases, tumors presented as uneven mixed high and low density mass in 5 cases and uniform low density in 1 case, which was cystic solid mass in 5 cases but solid mass in 1 case. The degree of 18F-FDG uptake increased of 5 cases, with the maximum standard uptake value (SUVmax) of 2.5-6.5 and the median of 6.2, 18F-FDG uptake was lower than that of adjacent renal parenchyma while in 1 case. Calcifications presented as scattered punctate/strip/nodular calcifications in the tumor or at the edges were detected in 5 cases. Renal vein/inferior vena cava tumor thrombi were noticed in 3 cases, characterized by thickenen venous lumen and increased radiation uptake. Distant metastases occurred in 2 cases, including lung metastases and multiple organ metastases in liver, lung and bones, respectively, with varying degrees of increased radiation uptake. Conclusion PET/CT manifestations of Xp11.2 translocation RCC had certain characteristics, which mainly presented as large soft tissue masses with cystic changes, calcifications and increased 18F-FDG uptake. |
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