| 肖力铭,于树鹏,徐微娜,孙艺珊,辛军.99Tcm-3PRGD2 SPECT/CT评估非小细胞肺癌淋巴结转移[J].中国医学影像技术,2023,39(6):853~856 |
| 99Tcm-3PRGD2 SPECT/CT评估非小细胞肺癌淋巴结转移 |
| 99Tcm-3PRGD2 SPECT/CT for evaluating lymph node metastases of non-small cell lung cancer |
| 投稿时间：2023-02-16 修订日期：2023-03-22 |
| DOI：10.13929/j.issn.1003-3289.2023.06.012 |
| 中文关键词: 癌,非小细胞肺 淋巴结转移 锝 体层摄影术,发射型计算机,单光子 体层摄影术,X线计算机 |
| 英文关键词:carcinoma, non-small-cell lung lymphatic metastasis technetium tomography, emission-computed, single-photon tomography, X-ray computed |
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| 中文摘要: |
| 目的 观察99Tcm-3PRGD2 SPECT/CT评估非小细胞肺癌（NSCLC）淋巴结转移的价值。方法 回顾性分析25例NSCLC患者99Tcm-3PRGD2 SPECT/CT资料；以术后病理结果为金标准，观察SPECT/CT定性（目视观察）及半定量分析[计算病灶/本底放射性计数比值(T/B)]评估NSCLC淋巴结转移的效能。结果 肺内NSCLC病灶均呈明显99Tcm-3PRGD2摄取阳性，其摄取程度差异无统计学意义（Z=－1.19，P=0.234）；伴与不伴淋巴结转移肺内原发灶之间T/B差异具有统计学意义（Z=－2.52，P=0.012）；以9.23为阈值，根据肺内原发灶T/B评估NSCLC淋巴结转移的AUC为0.79。共40个淋巴结区域存在转移，其中27个区域呈99Tcm-3PRGD2明显阳性摄取、13个区域呈轻度摄取或无摄取；131个区域为良性淋巴结，包括15个区域呈阳性摄取、116个区域呈阴性摄取。转移性与良性淋巴结之间，摄取99Tcm-3PRGD2程度差异具有统计学意义（Z=－7.19，P<0.001）；T/B差异亦有统计学意义（Z=－7.82，P<0.001）。淋巴结定性分析及半定量分析评估NSCLC淋巴结转移的曲线下面积（AUC）分别为0.78及0.91，差异具有统计学意义（Z=4.19，P<0.001）。结论 99Tcm-3PRGD2 SPECT/CT有助于评估NSCLC淋巴结转移。 |
| 英文摘要: |
| Objective To observe the value of 99Tcm-3PRGD2 SPECT/CT for evaluating lymph node metastases of non-small cell lung cancer (NSCLC). Methods Data of 99Tcm-3PRGD2 SPECT/CT in 25 NSCLC patients were retrospectively analyzed. Taken postoperative pathological results as gold standard, the efficacy of SPECT/CT qualitative analysis (visual observation) and semi quantitative analysis (calculation of ratio of tumor-to-background[T/B]) for evaluating lymph node metastases of NSCLC were explored.Results All primary lung tumors presented as significant positive uptake of 99Tcm-3PRGD2 on SPECT/CT, with no significant difference of uptake grades (Z=-1.19, P=0.234), while significant difference of T/B was found between primary lung tumors with or without lymph node metastases (Z=-2.52, P=0.012). Taken 9.23 as the threshold value, the area under the curve (AUC) of T/B of primary lung tumor for evaluating lymph node metastases was 0.79. Lymph node metastases were found in a total of 40 regions, including 27 regions with significant positive uptake and 13 regions with mild or without uptake of 99Tcm-3PRGD2. Meanwhile, benign lymph nodes were detected in 131 regions, including 15 regions with positive uptake and 116 regions without uptake of 99Tcm-3PRGD2. There was significant difference of uptake of 99Tcm-3PRGD2 existed between metastatic and benign lymph nodes (Z=-7.19, P<0.001), also of T/B between metastatic and benign lymph nodes (Z=-7.82, P<0.001). AUC of qualitative analysis and semi quantitative analysis for evaluating lymph node metastases of NSCLC was 0.78 and 0.91, respectively, which were significantly different (Z=4.19, P<0.001). Conclusion 99Tcm-3PRGD2 SPECT/CT was helpful for evaluating lymph node metastases of NSCLC. |
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