| 王悦,鞠烨,胡文君,王楠,林良杰,王家正,宋清伟,刘爱连.T1 mapping与R2* maps联合诊断慢性肾病[J].中国医学影像技术,2023,39(5):727~731 |
| T1 mapping与R2* maps联合诊断慢性肾病 |
| T1 mapping combined with R2* maps for diagnosing chronic kidney disease |
| 投稿时间：2022-12-09 修订日期：2023-04-05 |
| DOI：10.13929/j.issn.1003-3289.2023.05.020 |
| 中文关键词: 肾功能不全,慢性 磁共振成像 T1 mapping 横向弛豫 |
| 英文关键词:renal insufficiency, chronic magnetic resonance imaging T1 mapping transverse relaxation |
| 基金项目: |
| 作者 | 单位 | E-mail | | 王悦 | 大连医科大学附属第一医院放射科, 辽宁大连 116011 | | | 鞠烨 | 大连医科大学附属第一医院放射科, 辽宁大连 116011 | | | 胡文君 | 大连医科大学附属第一医院放射科, 辽宁大连 116011 | | | 王楠 | 大连医科大学附属第一医院放射科, 辽宁大连 116011 | | | 林良杰 | 飞利浦医疗科技, 北京 100600 | | | 王家正 | 飞利浦医疗科技, 北京 100600 | | | 宋清伟 | 大连医科大学附属第一医院放射科, 辽宁大连 116011
大连市医学影像人工智能工程技术研究中心, 辽宁大连 116011 | | | 刘爱连 | 大连医科大学附属第一医院放射科, 辽宁大连 116011
大连市医学影像人工智能工程技术研究中心, 辽宁大连 116011 | cjr.liuailian@vip.163.com |
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| 中文摘要: |
| 目的 观察T1 mapping与R2* maps联合诊断慢性肾病(CKD)的价值。方法 纳入27例CKD患者,根据改善全球肾脏病预后组织CKD分期标准将其分为A组(轻度肾损害,n=16)和B组(中重度肾损害,n=11),另纳入20名健康成年人作为对照组(C组);观察其肾脏T2WI、T1 mapping及R2* maps,比较3组间整体及两两间右肾皮、髓质T1值和R2*值差异,行logistic回归分析,评估右肾皮髓质T1值、R2*值和二者联合诊断CKD的效能。结果 3组间右肾皮质T1值及R2*值整体差异均有统计学意义(P均＜0.05),而髓质T1值及R2*值差异均无统计学意义(P均＞0.05);B组皮质T1值显著高于A组和C组(P均＜0.05),A组皮质R2*值显著高于B组和C组(P均＜0.05)。以右肾皮质T1值鉴别CKD轻度与中重度肾损害的曲线下面积(AUC)为0.77,鉴别CKD中重度肾损害与健康人的AUC为0.90;皮质R2*值鉴别CKD轻度与中重度肾损害的AUC为0.94,鉴别CKD轻度肾损害与健康人的AUC为0.88;皮质T1值与R2*值联合鉴别轻度CKD肾损害与中重度肾损害的AUC为0.97,与右肾皮质T1值的AUC差异有统计学意义(Z=2.14,P=0.033)。结论 T1 mapping与R2* maps联合有助于诊断CKD。 |
| 英文摘要: |
| Objective To observe the value of T1 mapping combined with R2* maps for diagnosing chronic kidney disease (CKD). Methods Totally 27 CKD patients were enrolled and divided into group A (mild renal damage, n=16) or B (moderate-severe renal damage, n=11) according to CKD staging criteria of Kidney Disease: Improving Global Outcomes. Meanwhile, 20 healthy adults were enrolled (group C). T2WI, T1 mapping and R2* maps of kidneys were acquired. T1 and R2* values of renal cortex and medulla of the right kidney were measured and compared among 3 groups also between each 2 groups. Logistic regression analysis was performed, the efficacies of T1, R2* values and the combination of renal cortex and medulla of the right kidney for diagnosing CKD were observed. Results There were significant differences of T1 and R2* values of renal cortex among 3 groups (both P＜0.05), but not of T1 nor R2* values of renal medulla (both P＞0.05). T1 value of renal cortex in group B was significantly higher than that in group A and group C (both P＜0.05), and R2* value of renal cortex in group A was significantly higher than that in group B and group C (both P＜0.05). The area under the curve (AUC) of T1 value of renal cortex for differentiating CKD with mild or moderate-severe renal damage was 0.77, for differentiating CKD with moderate severe renal damage or healthy adults was 0.90. AUC of R2* value of renal cortex for differentiating CKD with mild or moderate-severe renal damage was 0.94, for differentiating CKD with mild renal damage or healthy adults was 0.88. AUC of T1 value combined with R2* value of renal cortex for differentiating CKD with mild or moderate severe renal damage was 0.97, significantly different from that of T1 value of renal cortex (Z=2.14, P=0.033). Conclusion T1 mapping combined with R2* maps was helpful for diagnosing CKD. |
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