| 刘娜,张浩南,林良杰,宋清伟,苗延巍.2D-与3D-酰胺质子转移成像显示脑肿瘤图像质量与定量参数的一致性[J].中国医学影像技术,2023,39(4):509~513 |
| 2D-与3D-酰胺质子转移成像显示脑肿瘤图像质量与定量参数的一致性 |
| Consistencies of imaging quality and quantitative parameters of brain tumors using 2D- and 3D-amide proton transfer imaging |
| 投稿时间：2022-10-25 修订日期：2023-01-16 |
| DOI：10.13929/j.issn.1003-3289.2023.04.006 |
| 中文关键词: 脑肿瘤 磁共振成像 酰胺质子转移成像 |
| 英文关键词:brain neoplasms magnetic resonance imaging amide proton transfer imaging |
| 基金项目:辽宁省教育厅科学研究经费面上项目(LJKZ0856)、大连市科技创新基金计划项目(2020JJ27SN075)。 |
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| 中文摘要: |
| 目的 观察2D-与3D-酰胺质子转移(APT)成像显示脑肿瘤图像质量与定量参数的一致性,以及定量参数与肿瘤Ki-67指数的相关性。方法 对29例脑肿瘤患者采集头部平扫、增强MRI及2D-APT、3D-APT。分别于2D-APT和3D-APT图像上测量肿瘤实质区 、水肿区 及对侧正常表现脑白质区(CNAWM) 的非对称性磁化传递率(MTRasym),计算肿瘤实质区 及水肿区 与CNAWM的MTRasym的差值;观察基于2D-与3D-APT所获参数的差异及其一致性,计算图像对比噪声比(CNR)及主观评分,分析肿瘤Ki-67指数(n=17)与MTRasym(T)的相关性。结果 基于2D-与3D-APT所测肿瘤定量参数及图像CNR差异均无统计学意义(P均＞0.05)。2D-APT主观评分高于3D-APT(P＜0.05)。基于2D-与3D-APT所获MTRasym(T)、△MTRasym(T-C)及图像CNR的一致性良好(ICC=0.764、0.894、0.790,P均＜0.05),而MTRasym(E)、MTRasym(CNAWM)及△MTRasym(E-C)的一致性较差或一般(ICC=0.290、0.102、0.732,P均＜0.05)。脑肿瘤Ki-67指数 与2D-及3D-APT所测MTRasym(T)均呈正相关(r=0.524、0.513,P=0.031、0.035)。结论 2D-与3D-APT显示脑肿瘤图像CNR及定量参数无明显差异,且MTRasym(T)一致性良好;脑肿瘤MTRasym(T)均与Ki-67指数呈正相关。 |
| 英文摘要: |
| Objective To observe the consistencies of imaging quality and quantitative parameters of brain tumors using 2D- and 3D-amide proton transfer (APT) imaging, and the correlations of quantitative parameters and tumor Ki-67 index. Methods Head MRI, including conventional plain scan, enhanced MRI, also 2D- and 3D-APT were acquired in 29 patients with brain tumors. Magnetization transfer ratio asymmetry (MTRasym) in parenchymal area (MTRasym ) of the tumors, edema area (MTRasym ) and contralateral normal appearing white matter (CNAWM) (MTRasym ) were measured on 2D- and 3D-APT, respectively, and MTRasym difference in tumor parenchymal area (△MTRasym )and edema area (△MTRasym ) with CNAWM were calculated. The consistencyies of the above quantitative parameters obtained with 2D- and 3D-APT, image contrast noise ratio (CNR) and subjective score of the tumors were evaluated, and the correlation of MTRasym(T) and tumor Ki-67 index(n=17) was analyzed. Results There was no significant difference of the above quantitative parameters and image CNR obtained with 2D- and 3D-APT (all P＞0.05). The subjective score of 2D-APT was higher than that of 3D-APT (P＜0.05). MTRasym(T), △MTRasym(T-C) and image CNR obtained with 2D- and 3D-APT had good consistency (ICC=0.764, 0.894, 0.790, all P＜0.05), while the consistencies of MTRasym(E), MTRasym(CNAWM) and △MTRasym(E-C) was poor or general (ICC=0.290, 0.102, 0.732, all P＜0.05). Ki-67 index ( %) of 17 brain tumors was positively correlated with MTRasym(T) obtained with 2D- and 3D-APT (r=0.524, 0.513, P=0.031, 0.035). Conclusion CNR and quantitative parameters of brain tumors obtained with 2D- and 3D-APT were not significant different, and MTRasym(T) obtained with 2D- and 3D-APT were consistent and both positively correlated with Ki-67 index. |
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