| 陈茜,李亥辰,黎梅,张明星,唐铭悦.左心室心肌肥厚大鼠模型心肌应变参数与内皮功能的相关性[J].中国医学影像技术,2023,39(4):481~486 |
| 左心室心肌肥厚大鼠模型心肌应变参数与内皮功能的相关性 |
| Correlations of myocardial strain parameters and endothelial function in left ventricular hypertrophy rat models |
| 投稿时间：2022-11-21 修订日期：2023-01-04 |
| DOI：10.13929/j.issn.1003-3289.2023.04.001 |
| 中文关键词: 大鼠 心室功能,左 心肌病,肥厚性 磁共振成像 内皮功能 |
| 英文关键词:rats ventricular function, left cardiomyopathy, hypertrophic magnetic resonance imaging endothelium function |
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| 中文摘要: |
| 目的 观察左心室心肌肥厚大鼠心肌应变参数与内皮功能的相关性。方法 将18只无特定病原体(SPF)级雄性SD大鼠随机分为模型组和对照组,每组各9只。对模型组注射异丙肾上腺素(ISO) 构建左心室心肌肥厚大鼠模型,对照组注射等量生理盐水。行心脏MR扫描,获得心肌应变参数;采集静脉血,检测内皮素-1(ET-1)、循环内皮细胞(CEC)及NO水平,分析其与心肌应变参数的相关性。结果 模型组大鼠左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)及左心室心肌质量(LVM)均大于(P均＜0.01),左心室射血分数(LVEF)、左心室整体径向应变(LVGRS)、左心室整体圆周应变(LVGCS)及左心室整体纵向应变(LVGLS)均小于对照组(P均＜0.01)。模型组大鼠ET-1及CEC均明显高于(P均＜0.01)而NO低于对照组(P＜0.01)。大鼠LVGRS、LVGCS及LVGLS分别与ET-1、CEC及NO相关(|r|=0.522~0.786,P均＜0.05)。结论 左心室心肌肥厚大鼠模型心肌应变参数与ET-1、CEC及NO相关。 |
| 英文摘要: |
| Objective To observe the correlations of myocardial strain parameters and endothelial function in left ventricular hypertrophy rat models. Methods Eighteen specific pathogen free (SPF)-grade SD male rats were randomly divided into model group and control group (each n=9). Rat models of left ventricular hypertrophy were established through isoproterenol (ISO) injecting in model group, while rats in control group underwent injection of the same amount of saline. Cardiac MR scanning was performed after modeling to acquire myocardial strain parameters. Then venous blood was obtained, the levels of ndothelin-1 (ET-1), circulating endothelial cell (CEC) and NO were measured, and the correlations with myocardial strain parameters were analyzed. Results In model group, left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV) and left ventricular myocardial mass (LVM) were higher, but left ventricular ejection fraction (LVEF), left ventricular global radial strain (LVGRS), left ventricular global circumferential strain (LVGCS) and left ventricular global longitudinal strain (LVGLS) were lower than those in control group (all P＜0.01). ET-1 and CEC of model group were significantly higher, while NO was lower than that of control group (all P＜0.01). LVGRS, LVGCS and LVGLS were all correlated with ET-1, CEC and NO, respectively (|r|=0.522—0.786, all P＜0.05). Conclusion Myocardial strain parameters were correlated with ET-1, CEC and NO in left ventricular hypertrophy rat models. |
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