| 卓尹杰,孙建男,马焱鑫,何志伟.骨髓、脾脏FDG摄取水平与非小细胞肺癌临床病理特征[J].中国医学影像技术,2023,39(2):216~221 |
| 骨髓、脾脏FDG摄取水平与非小细胞肺癌临床病理特征 |
| FDG uptake level of bone marrow and spleen with clinicopathological features in non-small cell lung cancer patients |
| 投稿时间：2022-08-14 修订日期：2022-09-27 |
| DOI：10.13929/j.issn.1003-3289.2023.02.014 |
| 中文关键词: 癌,非小细胞肺 单核巨噬细胞系统 骨髓 脾 体层摄影术,X线计算机 正电子发射断层显像 18F氟脱氧葡萄糖 |
| 英文关键词:carcinoma, non-small-cell lung mononuclear phagocyte system bone marrow spleen tomography, X-ray computed positron-emission tomography fluorodeoxyglucose F18 |
| 基金项目: |
|
| 摘要点击次数: 1307 |
| 全文下载次数: 690 |
| 中文摘要: |
| 目的 观察18F-FDG PET/CT所示骨髓及脾脏FDG摄取水平与非小细胞肺癌（NSCLC）患者临床病理特征的关系。方法 纳入82例术前接受18F-FDG PET/CT检查的NSCLC患者（NSCLC组）及41例非肿瘤患者（对照组），比较2组骨髓、脾脏FDG摄取水平差异，观察其与临床病理特征之间的关系。结果 NSCLC组骨髓平均标准摄取值（SUVmean）、骨髓SUVmean与肝脏SUVmean比值（BLR），以及脾脏SUVmean与肝脏SUVmean比值（SLR）均高于对照组（P均<0.05）。男性患者、鳞癌、高TNM分期、肿瘤>3 cm及伴局部淋巴结转移者NSCLC原发灶的最大标准摄取值（SUVmax）更高（P均<0.05）；高TNM分期、肿瘤>3 cm及伴局部淋巴结转移患者骨髓SUVmean及BLR更高（P均<0.05）；高TNM分期及肿瘤>3 cm者SLR更高（P均<0.05）；TNM Ⅲ期肿瘤患者脾脏SUVmean高于TNM Ⅱ期（P<0.05）。结论 NSCLC患者骨髓及脾脏高FDG摄取水平与反映不良预后的肿瘤临床病理特征相关。 |
| 英文摘要: |
| Objective To explore the relationships of FDG uptake level of bone marrow and spleen on 18F-FDG PET/CT with clinicopathological features in patients with non-small cell lung cancer (NSCLC). Methods Totally 82 NSCLC patients who underwent preoperative 18F-FDG PET/CT examination (NSCLC group) and 41 non-tumor patients (control group) were enrolled. The levels of FDG uptake in bone marrow and spleen were compared between groups, and the relationships of FDG uptake and clinicopathological features were analyzed. Results The mean standard uptake value (SUVmean) of bone marrow, bone marrow to liver uptake ratio (BLR), as well as spleen to liver uptake ratio (SLR) in NSCLC group were all higher than those in control group (all P<0.05). NSCLC patients who were male, with squamous cell carcinoma, high TNM stage, tumor size >3 cm and local lymph node metastases had higher primary focus maximum standard uptake value (SUVmax) (all P<0.05). Patients with higher TNM stage, tumor size >3 cm and local lymph node metastases had higher bone marrow SUVmean and BLR (all P<0.05), with higher TNM stage and tumor size >3 cm had higher SLR (both P<0.05). Splenic SUVmean was only associated with TNM stage (P<0.05). Conclusion High FDG uptake of bone marrow and spleen in NSCLC patients were related to the clinicopathological features of tumor reflecting poor prognosis. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
