| 赵佳佳,邢媛媛,张欣,贾丽美,杨杰.肺孤立性结节样腺癌PET/CT表现与丙酮酸激酶M2、硒结合蛋白-1表达的相关性[J].中国医学影像技术,2022,38(12):1838~1842 |
| 肺孤立性结节样腺癌PET/CT表现与丙酮酸激酶M2、硒结合蛋白-1表达的相关性 |
| Correlations of PET/CT findings, expression of pyruvate kinase M2 and selenium binding protein 1 of pulmonary solitary nodular adenocarcinoma |
| 投稿时间：2022-06-21 修订日期：2022-08-26 |
| DOI：10.13929/j.issn.1003-3289.2022.12.016 |
| 中文关键词: 肺腺癌 丙酮酸激酶 硒结合蛋白质类 正电子发射断层显像 体层摄影术,X线计算机 |
| 英文关键词:adenocarcinoma of lung pyruvate kinase selenium-binding proteins positron-emission tomography tomography, X-ray computed |
| 基金项目:2021年承德市科学技术研究与发展计划项目（202109A054）。 |
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| 中文摘要: |
| 目的 观察肺孤立性结节样腺癌PET/CT表现与丙酮酸激酶M2（PKM2）、硒结合蛋白-1（SBP-1）表达的相关性。方法 以101例肺孤立性结节样腺癌为观察组，以68例肺良性肿瘤为对照组；比较2组病灶PKM2、SBP-1表达及PET/CT最大标准摄取值（SUVmax）、峰值标准摄取值（SUVpeak）和肿瘤代谢体积（MTV），分析观察组病灶PET/CT表现与PKM2、SBP-1表达的关系。结果 观察组病灶PKM2高表达率高于（P<0.001）、SBP-1高表达率低于对照组（P<0.001）；观察组病灶SUVmax、SUVpeak及MTV均高于对照组（P均<0.05）。观察组内PKM2高表达结节呈分叶状、多边形/不规则形、胸膜凹陷征占比及其SUVmax、SUVpeak和MTV均高于PKM2低表达结节（P均<0.05）；SBP-1高表达结节呈分叶状、胸膜凹陷征占比及其SUVmax、SUVpeak和MTV均低于SBP-1低表达结节（P均<0.05）。观察组病灶呈分叶状、出现胸膜凹陷征、SUVmax、SUVpeak及MTV均与其PKM2表达呈正相关、与SBP-1表达呈负相关（P均<0.05）。结论 肺孤立性结节样腺癌PET/CT表现与其PKM2及SBP-1表达相关。 |
| 英文摘要: |
| Objective To observe the correlations of PET/CT findings, expression of pyruvate kinase M2 (PKM2) and selenium binding protein 1 (SBP-1) of pulmonary solitary nodular adenocarcinoma. Methods A total of 101 patients with pulmonary solitary nodular adenocarcinoma (study group) and 68 patients with benign lung tumors (control group) were enrolled. The expression of PKM2 and SBP-1, the maximum standard uptake value (SUVmax), peak standard uptake value (SUVpeak) and metabolic tumor volume (MTV) of lesions were compared between groups. The correlations of PET/CT manifestations, the expression of PKM2 and SBP-1 of lesions in study group were analyzed. Results High expression rate of PKM2 of lesions in study group was higher (P<0.001), while of SBP-1 was lower than those in control group (P<0.001). SUVmax, SUVpeak and MTV of lesions in study group were all higher than those in control group (all P<0.05). In study group, the percentage of lobar sign, polygonal/irregular shape and pleural depression sign, as well as SUVmax, SUVpeak and MTV of nodules with high PKM2 expression were higher than those of nodules with low PKM2 expression (all P<0.05), while the percentage of lobar sign and pleural depression sign, as well as SUVmax, SUVpeak and MTV of nodules with high SBP-1 expression were lower than those of nodules with low SBP-1 expression (all P<0.05). The lobar sign, pleural depression sign, SUVmax, SUVpeak and MTV of lesions in study group were positively correlated with PKM2 expression but negatively correlated with SBP-1 expression (all P<0.05). Conclusion PET/CT findings of pulmonary solitary nodular adenocarcinoma were correlated with the expression of PKM2 and SBP-1. |
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