| 王晨阳,刘宴池,赵洪增,赵力聪,李杰,高燕,桑德恩,李文慧,王传升.格兰杰因果分析观察酒精依赖患者杏仁核与全脑效应连接特点[J].中国医学影像技术,2022,38(12):1807~1811 |
| 格兰杰因果分析观察酒精依赖患者杏仁核与全脑效应连接特点 |
| Granger causality analysis of characteristics of effect connections between amygdala and whole brain in alcohol-dependent patient |
| 投稿时间：2022-06-27 修订日期：2022-08-05 |
| DOI：10.13929/j.issn.1003-3289.2022.12.010 |
| 中文关键词: 酒精中毒 行为,成瘾 杏仁核 脑 格兰杰因果关系 磁共振成像 |
| 英文关键词:alcoholism behavior, addictive amygdala brain Granger causality magnetic resonance imaging |
| 基金项目:新乡市科技攻关计划项目（GG2020036）、河南省精神心理疾病临床医学研究中心开放课题（2020-zxkfkt-001）。 |
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| 中文摘要: |
| 目的 采用格兰杰因果分析观察酒精依赖患者杏仁核与全脑效应连接特点。方法 前瞻性纳入53例酒精依赖患者（病变组）及67名健康志愿者（对照组），基于格兰杰因果分析（GCA）观察功能MRI所示双侧杏仁核与全脑效应连接异常脑区，分析效应连接与酒精依赖年限、贝克抑郁量表（BDI）、贝克焦虑量表（BAI）及匹兹堡睡眠质量指数（PSQI）评分的相关性，观察其效应连接特点。结果 病变组左侧杏仁核至左侧颞中叶、左侧眶部额上回、Cerebelum_6_R、右侧颞上回及右侧中扣带回的效应连接，以及Cerebelum_6_R至左侧杏仁核的效应连接均高于对照组（P均<0.05），而右侧杏仁核至左侧海马旁回和右侧丘脑的效应连接均低于对照组（P均<0.05）。病变组左侧杏仁核至右侧中扣带回效应连接与BAI （r=0.409，P=0.002）及BDI评分（r=0.422，P=0.002）均呈正相关，左侧杏仁核至Cerebelum_6_R效应连接与酒精依赖年限（r=－0.297，P=0.031）及PSQI评分（r=－0.344，P=0.012）均呈负相关。结论 酒精依赖患者杏仁核与左侧颞中叶、左侧眶部额上回、Cerebelum_6_R、右侧颞上回、右侧中扣带回、左侧海马旁回及右侧丘脑效应连接异常，且与负性情绪相关。 |
| 英文摘要: |
| Objective To observe the characteristics of effect connections between amygdala and whole brain in alcohol-dependent patient. Methods Totally 53 alcohol-dependent patients (disease group) and 67 healthy volunteers (control group) were prospectively enrolled. Based on Granger causality analysis (GCA), the brain regions with abnormal effect connection between bilateral amygdala and whole brain were observed with functional MRI. The correlations of the effect connections and the years of alcohol dependence, Beck depression inventory (BDI), Beck anxiety inventory (BAI) and Pittsburgh sleep quality index (PSQI) were evaluated. The characteristics of the effect connections were analyzed. Results The effect connections of left amygdala to left middle temporal lobe, left orbital superior frontal gyrus, Cerebelum_6_R, right superior temporal gyrus and right middle cingulate gyrus, also of Cerebelum_6_R to left amygdala in disease group were all stronger (all P<0.05), while of right amygdala to left parahippocampal gyrus and right thalamus were weaker than those in control group (both P<0.05). In disease group, the effect connection of left amygdala to right middle cingulate gyrus was positively correlated with BAI (r=0.409, P=0.002) and BDI (r=0.422, P=0.002), while of left amygdala to Cerebelum_6_R was negatively correlated with the years of alcohol dependence (r=-0.297, P=0.031) and PSQI (r=-0.344, P=0.012). Conclusion The effect connections were abnormal between amygdala and left middle temporal lobe, left orbital superior frontal gyrus, Cerebelum_6_R, right superior temporal gyrus, right middle cingulate gyrus, left parahippocampal gyrus and right thalamus, and were related to the negative emotion. |
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