| 邹孝猛,毛盈譞,张羽,董天秀,杨秀华.超声靶向微泡破坏实现肿瘤递药研究进展[J].中国医学影像技术,2022,38(11):1739~1742 |
| 超声靶向微泡破坏实现肿瘤递药研究进展 |
| Progresses of ultrasound targeted microbubble destruction for antineoplastic drug delivery |
| 投稿时间：2021-12-15 修订日期：2022-05-03 |
| DOI：10.13929/j.issn.1003-3289.2022.11.033 |
| 中文关键词: 肿瘤 微泡 分子靶向治疗 超声检查 |
| 英文关键词:neoplasms microbubbles molecular targeted therapy ultrasonography |
| 基金项目:国家自然科学基金（81871362）、黑龙江省卫生计生委科研课题（2018414）。 |
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| 中文摘要: |
| 超声微泡（MB）是诊断成像及药物递送的重要载体。超声靶向微泡破坏（UTMD）技术具有安全、无创、高效且可控等优点。以低强度聚焦超声（LIFU）触发UTMD可将载药MB准确送达肿瘤组织，是极具前景的靶向递药方式。本文就UTMD作用机制及其用于肿瘤递药研究进展进行综述。 |
| 英文摘要: |
| Ultrasound microbubble (MB) is an important carrier for diagnostic imaging and drug delivery. Ultrasound-targeted microbubble destruction (UTMD) has advantages of being safe, non-invasive, efficient and controllable. Triggered by low-intensity focused ultrasound (LIFU), drug-carrying MB can accurately delivered to tumor tissue with UTMD technology, being a promising mode of targeted drug delivery. The mechanisms of UTMD and relative research progresses in antineoplastic drug delivery were reviewed in this paper. |
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