| 江建芹,符益纲,周笑,朱明明,徐高峰,胡春洪,邵伟伟.B1场校正T1 mapping测量肺癌初始T1值的可重复性及其与表观弥散系数和Ki-67表达的相关性[J].中国医学影像技术,2022,38(11):1652~1656 |
| B1场校正T1 mapping测量肺癌初始T1值的可重复性及其与表观弥散系数和Ki-67表达的相关性 |
| B1-corrected T1 mapping for measuring lung cancer native T1 value and correlations with apparent diffusion coefficient and Ki-67 expression |
| 投稿时间：2022-05-17 修订日期：2022-07-12 |
| DOI：10.13929/j.issn.1003-3289.2022.11.013 |
| 中文关键词: 肺肿瘤 弥散磁共振成像 Ki-67抗原 T1 mapping |
| 英文关键词:lung neoplasms diffusion magnetic resonance imaging Ki-67 antigen T1 mapping |
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| 中文摘要: |
| 目的 观察B1场校正MR纵向弛豫时间成像（T1 mapping）测量肺癌初始T1值的可重复性及其与弥散加权成像（DWI）定量参数表观弥散系数（ADC）及Ki-67表达的相关性。方法 收集36例经穿刺活检或手术病理确诊的肺癌患者，包括33例单发及3例多发共39个病灶；采集胸部B1场校正T1 mapping及DWI，以免疫组织化学检测方法评估病灶组织Ki-67表达水平。由2名影像科医师（观察者A、B）独立测量病灶初始T1值和ADC，评估观察者内及观察者间测量T1值的一致性及其差异，分析肺癌初始T1值、ADC及Ki-67表达的相关性。结果 观察者A所测肺癌初始T1值为（1 436.38±222.26）ms及（1 449.58±229.98）ms，差异无统计学意义（t=-0.960，P=0.343）；观察者B所测肺癌初始T1值为（1 461.30±236.44）ms，与观察者A差异无统计学意义（t=-1.532，P=0.134）；观察者内[组内相关系数（ICC）=0.963，95%CI（0.928，0.980）]与观察者间[ICC=0.948，95%CI（0.901，0.973）]测量肺癌初始T1值的一致性均较好。肺癌初始T1值与Ki-67表达呈中度正相关（r=0.448，P=0.004）、与ADC呈中度负相关（r=-0.558，P<0.001），ADC与Ki-67表达呈高度负相关（r=-0.605，P<0.001）。结论 B1场校正T1 mapping测量肺癌初始T1值可重复性好；肺癌初始T1值与ADC、Ki-67表达均呈中度相关。 |
| 英文摘要: |
| Objective To explore the reproducibility of B1-corrected T1 mapping for measuring lung cancer native T1 value and the correlations with quantitative parameter of apparent diffusion coefficient (ADC) of diffusion weighted imaging (DWI) and Ki-67 expression.Methods Thirty-six patients with lung cancer confirmed by biopsy or surgical pathology were collected, including 33 cases with single and 3 cases with multiple lesions, totally with 39 lesions. Chest B1-corrected T1 mapping and DWI were acquired, while immunohistochemistry of lesions were performed for Ki-67 expression level. The native T1 value and ADC of lung cancer were measured independently by 2 radiologists (observer A and observer B), respectively, the measured values were compared, the inter- and intra-observer consistency of native T1 value were evaluated, and the correlations of lung cancer native T1 value, ADC and Ki-67 expression were analyzed.Results The native T1 values of lung cancer measured twice by observer A were (1 436.38±222.26) ms and (1 449.58±229.98) ms, respectively, no significantly difference was found (t=-0.960, P=0.343). The native T1 value of lung cancer measured by observer B was (1 461.30±236.44) ms, being not significantly different compared with that of observer A (t=-1.532, P=0.134). Good intra- and interobserver consistency was found, with intra-class correlation coefficient of 0.963 (95%CI[0.928, 0.980]) and 0.948 (95%CI[0.901, 0.973]), respectively. Lung cancer native T1 values and Ki-67 expression were positively (r=0.448, P=0.004) but negatively moderately correlated with ADC (r=-0.558, P<0.001), while ADC were highly negatively correlated with Ki-67 expression levels (r=-0.605, P<0.001).Conclusion The reproducibility of native T1 value of lung cancer measured with B1-corrected T1 mapping was good. The native T1 value of lung cancer was moderately correlated with ADC and Ki-67 expression. |
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