| 赵佳佳,邢媛媛,杨静,贾丽美,张欣.超级迭代PET/CT定量参数联合癌胚抗原鉴别良、恶性孤立性肺结节[J].中国医学影像技术,2022,38(10):1497~1502 |
| 超级迭代PET/CT定量参数联合癌胚抗原鉴别良、恶性孤立性肺结节 |
| Super-iterative PET/CT quantitative parameters combined with carcinoembryonic antigen for differentiating benign and malignant solitary pulmonary nodules |
| 投稿时间：2022-04-15 修订日期：2022-06-08 |
| DOI：10.13929/j.issn.1003-3289.2022.10.013 |
| 中文关键词: 孤立性肺结节 癌胚抗原 体层摄影术,X线计算机 正电子发射断层显像 |
| 英文关键词:solitary pulmonary nodule carcinoembryonic antigen tomography, X-ray computed positron-emission tomography |
| 基金项目:河北省2020年度医学科学研究课题（20200182）。 |
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| 中文摘要: |
| 目的 观察超级迭代PET/CT定量参数联合癌胚抗原（CEA）鉴别良、恶性孤立性肺结节（SPN）的价值。方法 选取95例SPN患者，根据术后病理结果将其分为恶性组（n=75）及良性组（n=20）。比较肺结节最大标准摄取值（SUVmax）、峰值标准摄取值（SUVpeak）、最大瘦体标准摄取值（SULmax）、峰值瘦体标准摄取值（SULpeak）及CEA组间差异；绘制受试者工作特征曲线，观察以上参数单独及联合诊断良、恶性SPN的效能。结果 恶性组结节SUVmax、SUVpeak、SULmax、SULpeak及患者CEA均显著大于良性组（P均<0.05）。恶性组TNM Ⅱ期及存在淋巴结转移肺结节的SUVmax、SUVpeak、SULmax、SULpeak及患者CEA均显著大于TNM Ⅰ期及无明显淋巴结转移者（P均<0.05）。分别以2.01、1.14、1.08、0.83及4.69 ng/ml为SUVmax、SUVpeak、SULmax、SULpeak及患者CEA诊断良、恶性SPN的最佳截断值，其曲线下面积（AUC）分别为0.831、0.710、0.795、0.822及0.782；联合上述五项参数的AUC为0.913，大于各单一参数的AUC （Z=5.163、8.415、6.480、6.277、6.594，P均<0.05）。结论 超级迭代PET/CT定量参数联合CEA可鉴别诊断良、恶性SPN，并有助于评估肺癌TNM分期及淋巴结转移。 |
| 英文摘要: |
| Objective To observe the value of super-iterative PET/CT quantitative parameters combined with carcinoembryonic antigen (CEA) for differentiating benign and malignant solitary pulmonary nodules (SPN). Methods Totally 95 patients with SPN were enrolled and divided into malignant group (n=75) and benign group (n=20) according to postoperative pathological results. The maximum standard uptake value (SUVmax), peak standard uptake value (SUVpeak), the maximum standard uptake value normalized by lean body mass (SULmax) and peak standard uptake value normalized by lean body mass (SULpeak) of pulmonary nodules, as well as CEA were obtained and compared between groups. The receiver operating characteristic curves were drawn, and the efficacies of above parameters alone and the combination for differentiating benign and malignant SPN were observed. Results SUVmax, SUVpeak, SULmax, SULpeak of pulmonary nodules and patients' CEA in malignant group were significantly higher than those of benign group (all P<0.05). In malignant group, SUVmax, SUVpeak, SULmax, SULpeak of TNM stage Ⅱ pulmonary nodules and with lymph node metastasis, as well as patients' CEA were all significantly higher than those of TNM stage Ⅰ and without lymph node metastasis SPN(all P<0.05). Taken 2.01, 1.14, 1.08, 0.83 and 4.69 ng/ml as the best cut-off value of SUVmax, SUVpeak, SULmax, SULpeak and CEA for diagnosing benign and malignant SPN, respectively, the area under the curve (AUC) was 0.831, 0.710, 0.795, 0.822 and 0.782, respectively. The AUC of combination of the above 5 parameters was 0.913, significantly higher than that of each parameter alone (Z=5.163, 8.415, 6.480, 6.277, 6.594, all P<0.05). Conclusion Super-iterative PET/CT quantitative parameters combined with CEA could be used for differentiating benign and malignant SPN, being helpful to evaluating TNM stage and lymph node metastasis of SPN. |
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