| 华俊,杨媛媛,刘影,张伟,陈晓良.18F-前列腺特异性膜抗原-1007 PET/CT鉴别正常神经节与前列腺癌淋巴结转移[J].中国医学影像技术,2022,38(9):1371~1375 |
| 18F-前列腺特异性膜抗原-1007 PET/CT鉴别正常神经节与前列腺癌淋巴结转移 |
| 18F-prostate specific membrane antigen-1007 PET/CT for differentiating normal ganglia and lymph node metastasis of prostate cancer |
| 投稿时间：2022-01-07 修订日期：2022-07-17 |
| DOI：10.13929/j.issn.1003-3289.2022.09.020 |
| 中文关键词: 前列腺肿瘤 淋巴结转移 神经节 前列腺特异性膜抗原 体层摄影术,X线计算机 正电子发射断层显像 |
| 英文关键词:prostatic neoplasms lymphatic metastasis ganglia prostate specific membrane antigen tomography, X-ray computed positron-emission tomography |
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| 中文摘要: |
| 目的 观察18F-前列腺特异性膜抗原(PSMA)-1007 PET/CT鉴别正常神经节与前列腺癌淋巴结转移的价值。方法 回顾性分析80例接受早期及延迟期18F-PSMA-1007 PET/CT检查的前列腺癌患者，观察星状神经节、腹腔神经节及骶神经节的显示率，以及其与全身转移性淋巴结最大标准摄取值(SUVmax)和ΔSUVmax(延迟期SUVmax-早期SUVmax)的差异，评估PET/CT鉴别二者的价值。结果 80例中，60例(75.00%，60/80)PET/CT至少显示1个星状神经节/腹腔神经节/骶神经节；PET/CT对于腹腔神经节、星状神经节及骶神经节的显示率分别为66.25%(53/80)、56.25%(45/80)及30.00%(24/80)，差异有统计学意义(χ2=22.44，P<0.001)。星状神经节/腹腔神经节/骶神经节的早期、延迟期SUVmax及ΔSUVmax均显著低于转移性淋巴结(P均<0.001)。神经节与淋巴结的ΔSUVmax构成比差异有统计学意义(P<0.001)；神经节SUVmax多较稳定，淋巴结延迟期SUVmax多高于早期SUVmax。结论 18F-PSMA-1007 PET/CT有助于根据解剖位置及SUVmax鉴别正常神经节与前列腺癌淋巴结转移。 |
| 英文摘要: |
| Objective To observe the value of 18F-prostate specific membrane antigen (PSMA)-1007 PET/CT for differentiating normal ganglia and lymph node metastasis of prostate cancer. Methods Data of 80 patients with prostate cancer who underwent early and delayed 18F-PSMA-1007 PET/CT examinations were retrospectively analyzed. The display rates of stellate ganglion, celiac ganglion and sacral ganglion were observed, and the maximum standard uptake value (SUVmax) and ΔSUVmax (SUVmax in delayed phase-SUVmax in early phase) were compared between ganglia and systemic metastatic lymph nodes, hence the differential value of PET/CT was analyzed. Results Among 80 prostate cancer patients, PET/CT showed at least 1 ganglion (stellate/celiac/sacral) in 60 patients (75.00%, 60/80). The display rate of PET/CT of celiac ganglion, stellate ganglion and sacral ganglion was 66.25% (53/80), 56.25% (45/80) and 30.00% (24/80), respectively, with significant differences(χ2=22.44, P<0.001). SUVmax in early and delayed phase and ΔSUVmax of stellate/celiac/sacral ganglion were all significantly lower than those of metastatic lymph nodes (all P<0.001), and there was significant difference of the constituent ratio of ΔSUVmax between ganglion and lymph node (P<0.001). SUVmax of ganglions were rather stable, while of lymph node in delayed phase was higher than in early phase. Conclusion According to anatomical location and SUVmax, 18F-PSMA-1007 PET/CT was helpful for differentiating normal ganglia and lymph node metastasis of prostate cancer. |
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