| 张永海,杨林,黄尚勇,张晓敏,张勇,大旺堆,孟庆宁,史纲.定量磁化率成像评估高原人脑氧代谢的可行性[J].中国医学影像技术,2022,38(9):1307~1311 |
| 定量磁化率成像评估高原人脑氧代谢的可行性 |
| Feasibility of quantitative susceptibility mapping for evaluating cerebral metabolic of oxygen at high altitude |
| 投稿时间：2022-04-25 修订日期：2022-07-01 |
| DOI：10.13929/j.issn.1003-3289.2022.09.006 |
| 中文关键词: 高原 脑氧代谢率 血红蛋白 动脉氧饱和度 磁共振成像 |
| 英文关键词:plateau cerebral metabolic rate of oxygen hemoglobins arterial oxygen saturation magnetic resonance imaging |
| 基金项目:青海省基础研究计划（2018-ZJC-704）。 |
|
| 摘要点击次数: 2715 |
| 全文下载次数: 427 |
| 中文摘要: |
| 目的 观察定量磁化率成像(QSM)测量高原人脑氧代谢率(CMRO2)的可行性。方法 纳入高原(高原组)及平原地区(平原组)汉族健康志愿者各34名，测量其血红蛋白(Hb)水平、红细胞计数(RBC)及动脉血氧饱和度(SaO2)；利用QSM联合3D动脉自旋标记技术，获取静息态下大脑定量磁敏感值，利用后处理软件录入高原地区健康志愿者Hb和SaO2，计算全脑白质和灰质的氧摄取分数(OEF)、脑血流量(CBF)、动脉血氧含量(CaO2)及CMRO2，并与QSM常规方法所测平原组OEF及CMRO2进行比较。结果 高原组Hb及RBC均大于(P均<0.05)而SaO2小于平原组(P<0.05)；组间CaO2差异无统计学意义(P>0.05)。高原组脑白质及脑灰质OEF高于平原组(P均<0.05)；组间CBF及CMRO2差异均无统计学意义(P均>0.05)。结论 经校准Hb和SaO2后，QSM技术能更准确地反映高原人在低压、缺氧环境下的脑氧代谢情况。 |
| 英文摘要: |
| Objective To observe the feasibility of quantitative susceptibility mapping (QSM) for evaluating cerebral metabolic rate of oxygen (CMRO2) in plateau population. Methods Totally 34 healthy volunteers from plateau (plateau group) and 34 from plain (plain group) were enrolled. The hemoglobin (Hb) level, red blood cell count (RBC) and arterial oxygen saturation (SaO2) were measured. Combined with 3D arterial spin labeling, QSM was used to obtain quantitative magnetic sensitivity values of brain in resting state. Hb and SaO2 of plateau group were inputted by post-processing software, the oxygen extraction fraction (OEF), cerebral blood flow (CBF), oxygen content in arterial blood (CaO2) as well as CMRO2 of white matter and gray matter in whole brain were calculated, and compared with OEF and CMRO2 derived with plain group through ordinary QSM methods. Results Hb and RBC in plateau group were higher (both P<0.05), while SaO2 was lower than those in plain group (P<0.05). There was no significant differences of CaO2 between groups (all P>0.05). OEF of white matter and gray matter in plateau group was higher than that in plain group (both P<0.05). There was no significant differences of CBF nor CMRO2 between groups (all P>0.05). Conclusion Calibrated by Hb and SaO2, QSM technique could accurately reflect the cerebral oxygen metabolism of people at high altitude under hypobaric hypoxia environment. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
