| 马萧童,刘耔宜,强昆,薛靖文,薛旭升,郑运松.原发性痛经机制及针灸疗效[J].中国医学影像技术,2022,38(9):1301~1306 |
| 原发性痛经机制及针灸疗效 |
| Pathogenesis of primary dysmenorrhea and therapeutic effect of acupuncture |
| 投稿时间：2022-04-11 修订日期：2022-06-05 |
| DOI：10.13929/j.issn.1003-3289.2022.09.005 |
| 中文关键词: 痛经 针刺 磁共振成像 前瞻性研究 |
| 英文关键词:dysmenorrhea acupuncture magnetic resonance imaging prospective studies |
| 基金项目:陕西中医药大学校级科研课题（2021CX20）、北京中医药大学孙思邈研究院2021年度中医药科研项目（SSMYJY-2-2021-16）、陕西中医药大学2021年度大学生创新创业训练计划（202110716013）。 |
|
| 摘要点击次数: 1866 |
| 全文下载次数: 471 |
| 中文摘要: |
| 目的 观察原发性痛经(PDM)发病机制及针灸疗效。方法 前瞻性纳入20例PDM患者(PDM组)及27名健康女性，于经期行痛经相关评分量表评估，采集头颅低频振幅(ALFF)及度中心性(DC)静息态功能MRI(rs-fMRI)；之后对PDM组行针灸治疗，于其后行第二次量表评估并采集rs-fMRI，比较治疗前、后组间及组内脑区ALFF值及DC值差异。结果 PDM组针灸治疗前痛经评分显著高于HC组及该组针灸后(P均<0.05)。PDM组右侧背外侧额上回(SFGdor)ALFF值及左侧颞中回(MTG)、左侧SFGdor、左侧后扣带回DC值均高于HC组(P均<0.05)，而左侧脑岛ALFF值低于HC组(P=0.043)。PDM组内针灸后双侧脑岛ALFF值及左侧中央后回、左侧中央旁小叶DC值均高于针灸前(P均<0.05)，而左侧颞下回、右侧MTG、左侧枕中回、右侧楔前叶ALFF值及左侧壳核/尾状核、右侧壳核DC值均低于针灸前(P均<0.05)。结论 PDM患者经期多个脑区功能异常，针灸治疗有助于改善。 |
| 英文摘要: |
| Objective To explore the pathogenesis of primary dysmenorrhea (PDM), and to observe the therapeutic effect of acupuncture. Methods Twenty PDM patients (PDM group) and 27 healthy young women (healthy control group) were prospectively enrolled, and dysmenorrhea related score scale evaluation, amplitude of low frequency fluctuation (ALFF) and degree centrality (DC) resting-state functional MRI (rs-fMRI) of brain were performed during menstruation. Then PDM patients underwent acupuncture, and scale evaluation and brain rs-fMRI were performed again during menstruation after acupuncture. ALFF and DC values of brain regions were compared between groups and within PDM group before and after acupuncture. Results The scores of dysmenorrhea of PDM group before acupuncture were significantly higher than after acupuncture and of HC group (all P<0.05). ALFF value of right dorsolateral superior frontal gyrus (SFGdor), DC values of left middle temporal gyrus (MTG), left SFGdor and left posterior cingulate gyrus in PDM group were all higher than those in HC group (all P<0.05), while ALFF value of left insula was lower in PDM group than that in HC group (P=0.043). In PDM group, ALFF values of bilateral insula, DC values of left postcentral gyrus and left paracentral lobule after acupuncture were higher all than those before acupuncture (all P<0.05), while ALFF values of left inferior temporal gyrus, right MTG, left middle occipital gyrus and right precuneus, as well as DC values of left putamen/caudate and right putamen were all lower than those before acupuncture (all P<0.05). Conclusion Abnormal brain regions existed in PDM patients, and acupuncture was helpful for treatment. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
