| 何升级,刘帅,张辉,霍力,尚斐.基于交替方向乘子法(ADMM)直接重建心脏11C-acetate PET动力学参数图[J].中国医学影像技术,2022,38(5):758~763 |
| 基于交替方向乘子法(ADMM)直接重建心脏11C-acetate PET动力学参数图 |
| Direct reconstruction of cardiac 11C-acetate PET kinetic parametric images based on alternating direction method of multipliers (ADMM) |
| 投稿时间：2020-12-15 修订日期：2022-01-04 |
| DOI：10.13929/j.issn.1003-3289.2022.05.029 |
| 中文关键词: 心脏 非线性动力学 正电子发射断层显像 示踪剂 交替方向乘子法 |
| 英文关键词:heart nonlinear dynamics positron-emission tomography tracer alternating direction method of multipliers |
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| 中文摘要: |
| 目的 观察基于交替方向乘子法(ADMM)直接重建心脏11C-acetate PET动力学参数图的价值。 方法 基于1例早期酒精性心肌病患者的心脏11C-acetate PET图像构建理想动态图像,通过投影生成正弦图,加入泊松噪声,并将PET图像重建与基于心脏11C-acetate单室模型动力学参数计算结合,采用ADMM直接重建心脏11C-acetate PET动力学参数图;基于有序子集最大期望值法(OSEM)间接重建心脏参数图。观察两种重建方法与参考标准的相关性,评估直接重建法的价值。结果 间接重建法耗时23 min,直接重建法耗时140 min。参考标准与通过间接重建得到的K1、k2和vl值的平均偏差分别为2.97%、1.61%和10.19%,与通过直接重建得到的K1、k2和vl值的平均偏差分别为1.16%、1.06%和4.30%。参考标准与通过间接重建或直接重建得到的K1、k2和vl均呈高度相关(r均＞0.9,P均＜0.001)。结论 相比间接重建法,基于ADMM直接重建心脏11C-acetate PET动力学参数图的准确性更高。 |
| 英文摘要: |
| Objective To observe the value of direct reconstruction of cardiac 11C-acetate PET kinetic parametric images based on alternating direction method of multipliers (ADMM).Methods Data of 11C-acetate PET images of 1 patient with early alcoholic cardiomyopathy was used to generate the ideal dynamic images, and the images were then projected to generate sinograms and added Poisson noise. PET images reconstruction were combined with the parameters calculation based on cardiac 11C-acetate single tissue compartment model, and the cardiac 11C-acetate PET kinetic parametric images were directly reconstructed with ADMM. The parametric images were indirectly reconstructed with ordered subsets expectation maximization (OSEM). The correlations of two reconstruction methods and reference standard were observed, and the value of direct reconstruction method was analyzed.Results The indirect reconstruction took 23 min, while the direct reconstruction took 140 min. The average biases of K1, k2 and vl calculated with reference standard and indirect reconstruction was 2.97%, 1.61% and 10.19%, respectively, while between reference standard and direct reconstruction was 1.16%, 1.06% and 4.30%, respectively. K1, k2 and vl calculated with indirect or direct reconstruction were all strongly correlated with reference standard (all r＞0.9, all P＜0.001).Conclusion Compared with indirect reconstruction, the accuracy of direct reconstruction of cardiac 11C-acetate PET kinetic parametric images based on ADMM was higher. |
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